Kidney health management during pregnancy: a dialogue between patients and healthcare professionals

Authors

  • Anna Laura Fantuzzi Dietista già Coordinatore Nutrizione e Dietetica Aziendale, AUSL Modena, Comitato Scientifico ASAND (Associazione Scientifica Alimentazione Nutrizione e Dietetica), Modena - Italy
  • Elisa Berri Dietista, Dipartimento di Cure Primarie, AUSL-IRCCS di Reggio Emilia - Italy https://orcid.org/0000-0003-1431-6551
  • Lida Tartaglione Dirigente Medico, UOC Nefrologia, AOU Policlinico Umberto I di Roma - Italy
  • Marcora Mandreoli MD, Comitato Tecnico Scientifico Progetto regionale PIRP (Prevenzione Insufficienza Renale Progressiva) - Italy https://orcid.org/0000-0003-0117-4857
  • Rossella Giannini Dietista, SSD Malattie del Metabolismo e Nutrizione Clinica Azienda Ospedaliero-Universitaria Policlinico di Modena - Italy
  • Sara Dominjanni Dirigente Medico, UOC Nefrologia e Dialisi Ospedale Sant’Eugenio, ASL Roma 2, Roma - Italy
  • Silvia Porreca Dirigente Medico, UOC Nefrologia e Dialisi, P.O. “Di Venere”, Bari, ASL BA, Bari - Italy https://orcid.org/0000-0002-5636-1361

DOI:

https://doi.org/10.33393/gcnd.2024.3180

Keywords:

Chronic kidney disease, Nutrition, Peritoneal dialysis, Pregnancy, Renal transplant

Abstract

Pregnancy in patients with chronic kidney disease (CKD) represents a significant challenge for nephrologists and healthcare professionals involved in the care pathway, especially in advanced stages of the disease and during dialysis. From an epidemiological standpoint, the exact percentage of women with CKD who become pregnant is unknown. It is estimated that stages 1 and 2 of kidney disease (where kidney function is still preserved or mildly impaired with persistent albuminuria) affect up to 3% of women of childbearing age (20-39 years), while stages 3-5 (glomerular filtration rate < 60 mL/min) affect about 1 out of 150 women of childbearing age. However, due to reduced fertility, these women often experience spontaneous miscarriages in the early months of pregnancy, and 1 out of 750 faces complications in her offspring.

As a result, managing pregnancy in CKD patients requires special attention, considering various clinical aspects including the reciprocal influence between the disease and pregnancy, the need to adjust therapies, the modification of treatments, and the high risk of maternal and fetal complications. An appropriate nutritional approach is also a crucial phase in this process, as nutritional status significantly influences maternal and fetal health. In this article, developed through questions posed to physicians and the case manager during routine care, we do not intend to address the entire complex issue linking kidney disease to pregnancy outcomes. Instead, we aim to provide updated answers to various topics of interest for the multidisciplinary team to safeguard the health of both mother and child.

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References

Holley JL, Schmidt RJ. Changes in fertility and hormone replacement therapy in kidney disease. Adv Chronic Kidney Dis. 2013;20(3):240-245. https://doi.org/10.1053/j.ackd.2013.01.003 PMID:23928388

Gonzalez Suarez ML, Parker AS, Cheungpasitporn W. Pregnancy in Kidney Transplant Recipients. Adv Chronic Kidney Dis. 2020 Nov;27(6):486-498. doi: 10.1053/j.ackd.2020.06.004. PMID: 33328065

Shah S, Venkatesan RL, Gupta A, et al. Pregnancy outcomes in women with kidney transplant: metaanalysis and systematic review. BMC Nephrol. 2019;20(1):24. https://doi.org/10.1186/s12882-019-1213-5 PMID:30674290

Williams D, Davison J. Chronic kidney disease in pregnancy. BMJ. 2008;336(7637):211-215. https://doi.org/10.1136/bmj.39406.652986.BE PMID:18219043

Shahir AK, Briggs N, Katsoulis J, Levidiotis V. An observational outcomes study from 1966-2008, examining pregnancy and neonatal outcomes from dialysed women using data from the ANZDATA Registry Nephrology (Carlton). 2013; 18: 276-84. https://doi.org/10.1111/nep.12044.

Cheung KL, Lafayette RA. Renal physiology of pregnancy. Adv Chronic Kidney Dis. 2013;20(3):209-214. https://doi.org/10.1053/j.ackd.2013.01.012 PMID:23928384

Castanys-Muñoz E, Kennedy K, Castañeda-Gutiérrez E, Forsyth S, Godfrey KM, Koletzko B, Ozanne SE, Rueda R, Schoemaker M, van der Beek EM, van Buuren S, Ong KK. Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatr. 2017 Aug;106(8):1230-1238. doi: 10.1111/apa.13868. PMID: 28382722

Hall M. Pregnancy in women with CKD: a success story. Am J Kidney Dis. 2016;68(4):633-639. https://doi.org/10.1053/j.ajkd.2016.04.022 PMID:27350132

Piccoli GB, Cabiddu G, Attini R, et al. Risk of adverse pregnancy outcomes in women with CKD. J Am Soc Nephrol. 2015;26(8):2011-2022. https://doi.org/10.1681/ASN.2014050459 PMID:25766536

Jungers P, Houillier P, Forget D, et al. Influence of pregnancy on the course of primary chronic glomerulonephritis. Lancet. 1995;346(8983):1122-1124. https://doi.org/10.1016/S0140-6736(95)91798-5 PMID:7475601

Cabiddu G, Castellino S, Gernone G, et al. A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy. J Nephrol. 2016;29(3):277-303. https://doi.org/10.1007/s40620-016-0285-6 PMID:26988973

Davison JM, Lindheimer MD. Pregnancy and chronic kidney disease. Semin Nephrol. 2011;31(1):86-99. https://doi.org/10.1016/j.semnephrol.2010.10.008 PMID:21266267

Nevis IF, Reitsma A, Dominic A, et al. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol. 2011;6(11):2587-2598. https://doi.org/10.2215/CJN.10841210 PMID:21940842

Michelle A. Hladunewich MA, Melamed N, Bramham K. Pregnancy across the spectrum of chronic kidney disease. Kidney Int. 2016;89(5):995-1007. https://doi.org/10.1016/j.kint.2015.12.050

Mehrabadi A, Liu S, Bartholomew S, et al; Canadian Perinatal Surveillance System Public Health Agency of Canada. Hypertensive disorders of pregnancy and the recent increase in obstetric acute renal failure in Canada: population based retrospective cohort study. BMJ. 2014;349(jul30 2):g4731. https://doi.org/10.1136/bmj.g4731 PMID:25077825

Piccoli GB, Alrukhaimi M, Liu Z-H, Zakharova E, Levin A; World Kidney Day Steering Committee. What we do and do not know about women and kidney diseases - questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Woman’s Day. Nephrology (Carlton). 2018;23(3):199-209. https://doi.org/10.1111/nep.13193 PMID:29131451

Gonzalez Suarez ML, Kattah A, Grande JP, Garovic V. Renal Disorders in Pregnancy: Core Curriculum 2019. Am J Kidney Dis. 2019 Jan;73(1):119-130. doi: 10.1053/j.ajkd.2018.06.006 PMID: 30122546

Provenzano M, Mancuso C, Garofalo C, De Nicola L, Andreucci M. Temporal variation of Chronic Kidney Disease’s epidemiology. G Ital Nefrol. 2019;36 (2).

De Nicola L, Donfrancesco C, Minutolo R, et al. Epidemiologia della MRC in Italia: stato dell’arte e contributo dello studio CHARES. G Ital Nefrol. 2011;28:401-407. PMID:21809309

De Nicola L, Donfrancesco C, Minutolo R, et al. Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008–12 National Health Examination Survey. Nephrol Dial Transplant 2015; 30: 806–814 doi: 10.1093/ndt/gfu383 PMID: 25523453

Documento di indirizzo per la malattia renale cronica (5.11.2014). Online https://www.salute.gov.it/portale/documentazione/p6_2_2_1.jsp?id=2244 (Accessed June 2024)

National Kidney Foundation. Clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002, 39: S1-S266. PMID: 11904577

Bastos MG, Kirsztajn GM. Chronic kidney disease: importance of early diagnosis, immediate referral and structured interdisciplinary approach to improve outcomes in patients not yet on dialysis. J Bras Nefrol. 2011;33(1):93-108. https://doi.org/10.1590/S0101-28002011000100013 PMID:21541469

Dao KH, Bermas BL. Systemic Lupus Erythematosus Management in Pregnancy. Int J Womens Health. 2022;14:199-211. CrossRef (https://doi.org/10.2147/IJWH.S282604) Pubmed (https://www.ncbi.nlm.nih.gov/pubmed/35210867)

Mehta B, Luo Y, Xu J, et al. Trends in maternal and fetal outcomes among pregnant women with systemic lupus erythematosus in the United States: a cross-sectional analysis. Ann Intern Med 2019;171(3):164e71. https://doi.org/10.7326/M19-0120

Gohr M, Jakobsen IM, Helmig RB, Stengaard-Pedersen K, Laurberg TB, Troldborg A. Improved pregnancy outcomes in systemic lupus erythematosus: A retrospective study of pregnancies from a single centre in Denmark from 2010-2020 compared with the period 1990-2010. Lupus. 2022;31(10):1202-1210. https://doi.org/10.1177/09612033221107538 PMID:35676102

Ponticelli C, Moroni G. Fetal Toxicity of Immunosuppressive Drugs in Pregnancy. J Clin Med. 2018;7(12):552. https://doi.org/10.3390/jcm7120552 PMID:30558290

Zucchi D, Fischer-Betz R, Tani C. Pregnancy in systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2023 Dec;37(4):101860. CrossRef (link: https://doi.org/10.1016/j.berh.2023.101860) PubMed (link: https://pubmed.ncbi.nlm.nih.gov/37596173/)

Mehta B, Jannat-Khah D, Glaser KK, et al. Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis. RMD Open. 2023;9(1):e002752. https://doi.org/10.1136/rmdopen-2022-002752 PMID:37185223

Moroni G, Doria A, Giglio E, et al. Fetal outcome and recommendations of pregnancies in lupus nephritis in the 21st century. A prospective multicenter study. J Autoimmun. 2016;74:6-12. https://doi.org/10.1016/j.jaut.2016.07.010 PMID:27496151

Wagner SJ, Craici I, Reed D, et al. Maternal and foetal outcomes in pregnant patients with active lupus nephritis. Lupus. 2009;18(4):342-347. https://doi.org/10.1177/0961203308097575 PMID:19276302

Clark CA, Spitzer KA, Laskin CA. Decrease in pregnancy loss rates in patients with systemic lupus erythematosus over a 40-year period. J Rheumatol. 2005;32(9):1709-1712. PMID:16142865

Moroni G, Ponticelli C. Important considerations in pregnant patients with lupus nephritis. Expert Rev Clin Immunol. 2018;14(6):489-498. https://doi.org/10.1080/1744666X.2018.1476139 PMID:29764231

Silver R, Craigo S, Porter F, Osmundson SS, Kuller JA, Norton ME; Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org. Society for Maternal-Fetal Medicine Consult Series #64: systemic lupus erythematosus in pregnancy. Am J Obstet Gynecol. 2023;228(3):B41-B60. https://doi.org/10.1016/j.ajog.2022.09.001 PMID:36084704

Mantovani A, Baldi F. Alimentazione e gravidanza: il decalogo proposto dall’ISS. Semplici regole per non esporsi troppo. Online: https://www.iss.it/nutrizione/-/asset_publisher/ZoYd2rXDJde2/content/-decalogo-nutrizione-e-sicurezza-alimentare-in-gravidanza-10-regole-per-non-esporsi-troppo (Accessed June 2024)

Cianciaruso B, Bellizzi V, Brunori G, et al. [Low-protein diet in Italy today: the conclusions of the Working Group from the Italian Society of Nephrology]. G Ital Nefrol. 2008;25(suppl 42):S54-S57. PMID:18828136

Fouque D, Aparicio M. Eleven reasons to control the protein intake of patients with chronic kidney disease. Nat Clin Pract Nephrol. 2007;3(7):383-392. https://doi.org/10.1038/ncpneph0524 PMID:17592471

Fouque D, Guebre-Egziabher F. Do low-protein diets work in chronic kidney disease patients? Semin Nephrol. 2009;29(1):30-38. https://doi.org/10.1016/j.semnephrol.2008.10.005 PMID:19121472

Esposito P, Garibotto G, Picciotto D, Costigliolo F, Viazzi F, Conti NE. Nutritional Challenges in Pregnant Women with Renal Diseases: Relevance to Fetal Outcomes. Nutrients. 2020;12(3):873. PMID:32213942 https://doi.org/10.3390/nu12030873 PMID:32213942

Reyes-López MA, Piccoli GB, Leone F, Orozco-Guillén A, Perichart-Perera O. Nutrition care for chronic kidney disease during pregnancy: an updated review. Eur J Clin Nutr. 2020l;74(7):983-990. PMID:31925336 https://doi.org/10.1038/s41430-019-0550-6 PMID:31925336

Wiggins KL. Nutrition care of adult pregnant ESRD patients. In: Burrowes J, ed. Nutrition Care of Renal Patients. 3rd ed. The American Dietetic Association; 2002.

Institute of Medicine (US) and National Research Council. (US) Committee to Reexamine IOM Pregnancy Weight Guidelines; Rasmussen KM, Yaktine AL, editors. Weight Gain During Pregnancy: Reexamining the Guidelines. Washington (DC): National Academies Press (US); 2009. 7, Determining Optimal Weight Gain. Online: https://www.ncbi.nlm.nih.gov/books/NBK32801/ (Accessed June 2024)

Ikizler TA, Burrowes JD, Byham-Gray LD, et al. KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. Am J Kidney Dis. 2020;76(3)(suppl 1):S1-S107. https://doi.org/10.1053/j.ajkd.2020.05.006 PMID:32829751

Piccoli GB, Conijn A, Consiglio V, et al. Pregnancy in dialysis patients: is the evidence strong enough to lead us to change our counseling policy? Clin J Am Soc Nephrol. 2010;5(1):62-71. https://doi.org/10.2215/CJN.05660809 PMID:19965547

Hladunewich M, Hercz AE, Keunen J, Chan C, Pierratos A. Pregnancy in end stage renal disease. Semin Dial. 2011;24(6):634-639. https://doi.org/10.1111/j.1525-139X.2011.00996.x PMID:22122666

Jain S, Schrader R, Austen L, et al. Pregnancy in women on chronic dialysis: a single-center experience. Int J Nephrol. 2011;2011:435151.

Manisco G, Poti M, Maggiulli G, Losappio V, Vernaglione L. Pregnancy and dialysis: a review of outcomes, complications, and management. Int J Womens Health. 2016;8:7-85.

Piccoli GB, Fassio F, Attini R, et al. Pregnancy in CKD: whom should we follow and why? Nephrol Dial Transplant. 2012;27(suppl 3):iii111-iii118. https://doi.org/10.1093/ndt/gfs302 PMID:22773243

Deshpande NA, James NT, Kucirka LM, et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant. 2011;11(11):2388-2404. https://doi.org/10.1111/j.1600-6143.2011.03656.x PMID:21794084

Kim HW, Seok HJ, Kim TH, Han DJ, Yang WS, Park SK. The experience of pregnancy after renal transplantation: pregnancies even within postoperative 1 year may be tolerable. Transplantation. 2008;85(10):1412-1419. https://doi.org/10.1097/TP.0b013e318170f8ed PMID:18497680

Stratta P, Canavese C, Giacchino F, Mesiano P, Quaglia M, Rossetti M. Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities. J Nephrol. 2003;16(6):792-806. PMID:14736006

Armenti VT, McGrory CH, Cater JR, Radomski JS, Moritz MJ. Pregnancy outcomes in female renal transplant recipients. Transplant Proc. 1998;30(5):1732-1734. https://doi.org/10.1016/S0041-1345(98)00408-4 PMID:9723259

Rowinski W; EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section IV: long-term management of the transplant recipient. Nephrol Dial Transplant. 2002;17(90004)(suppl 4):1-67. https://doi.org/10.1093/ndt/17.suppl_4.1-a PMID:12484407

Additional Files

Published

2024-09-12

How to Cite

Fantuzzi, A. L., Berri, E., Tartaglione, L., Mandreoli, M., Giannini, R., Dominjanni, S., & Porreca, S. (2024). Kidney health management during pregnancy: a dialogue between patients and healthcare professionals. Giornale Di Clinica Nefrologica E Dialisi, 36(1), 59–66. https://doi.org/10.33393/gcnd.2024.3180

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Original articles

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Received 2024-06-25
Accepted 2024-07-15
Published 2024-09-12

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