Intradialytic parenteral nutrition in patients with moderate-severe malnutrition: a multicentre experience


  • Concetto Sessa U.O.C. Nefrologia e Dialisi, P.O. “Maggiore” di Modica, Ragusa - Italy
  • Walter Morale U.O.C. Nefrologia e Dialisi, P.O. “Maggiore” di Modica, Ragusa - Italy
  • Antonino Reina U.O.C. Nefrologia e Dialisi, P.O. S. Marta e S. Venera, Acireale (CT) - Italy
  • Giorgio Battaglia U.O.C. Nefrologia e Dialisi, P.O. S. Marta e S. Venera, Acireale (CT) - Italy
  • Sandra La Rosa U.O. Nefrologia e Dialisi, P.O. “Giovanni Paolo II” Sciacca, Agrigento - Italy
  • Daniela Puliatti U.O.C. Nefrologia, A.O. per l’Emergenza “Cannizzaro”, Catania - Italy
  • Giuseppe Seminara U.O.C. Nefrologia, A.O. per l’Emergenza “Cannizzaro”, Catania - Italy
  • Luca Zanoli Nefrologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Catania, Catania - Italy



Dialysis, Intradialytic parenteral nutrition, Malnutrition, Nutritional supplementation, Protein energy wasting


Dialysis patients have a wide range of pathologies that contribute to their frailty. Maintaining a good nutritional status is useful to prevent and treat the so-called Protein-Energy Wasting (PEW), a complex clinical-laboratory condition in which a protein-energy depletion occurs. Adherence to a proper nutritional therapy in CKD requires considerable effort from both patients and health personnel (doctors and nurses). In order to slow down the effects of malnutrition and the disasters that complicate PEW, nephrologists can use supplementation products. In our observational, prospective, multicentre study, we administered an intradialytic parenteral nutrition of a three-compartment emulsion for intravenous infusion through an infusion pump connected to the venous line. After 12 weeks of treatment, subjects with severe malnutrition were reduced from 61.1% to 33.3%, serum creatinine increased by 16% (from 6.00 ± 1.48 mg/dL to 6.98 ± 2.46 mg/dL; P < 0.001), total protein and albumin levels respectively by 13% (from 5.46 ± 0.63 g/dL to 6.19 ± 0.66 g/dL; P < 0.001) and 19% (from 2.70 ± 0.48 g/dL to 3.20 ± 0.57 g/dL; P < 0.001), body weight by 3% (from 55.7 ± 13.2 kg to 57.6 ± 13.0 kg; P < 0.001).


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How to Cite

Sessa, C., Morale, W., Reina, A., Battaglia, G., La Rosa, S., Puliatti, D., Seminara, G., & Zanoli, L. (2021). Intradialytic parenteral nutrition in patients with moderate-severe malnutrition: a multicentre experience. Giornale Di Clinica Nefrologica E Dialisi, 33(1), 102–111.



Original articles


Received 2021-08-30
Accepted 2021-08-30
Published 2021-09-16


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