Vitamina D e prevenzione cardiovascolare

Luca Di Lullo; Rodolfo Rivera; Fulvio Floccari; Vincenzo Barbera; Antonio Bellasi; Antonio De Pascalis; Domenico Russo; Luigi Russo; Francesca Santoboni; Claudio Ronco

doi:10.33393/gcnd.2016.750

Authors

Luca Di Lullo U.O.C. Nefrologia e Dialisi, Ospedale Parodi-Delfino, Colleferro (RM)
Rodolfo Rivera Divisione di Nefrologia, Ospedale S. Gerardo, Monza
Fulvio Floccari U.O.C. Nefrologia e Dialisi, Ospedale S. Paolo, Civitavecchia (RM)
Vincenzo Barbera U.O.C. Nefrologia e Dialisi, Ospedale Parodi-Delfino, Colleferro (RM)
Antonio Bellasi U.O.C. Nefrologia e Dialisi, ASST Lariana, Como
Antonio De Pascalis U.O.C. Nefrologia e Dialisi, Ospedale V. Fazzi, Lecce
Domenico Russo Cattedra di Nefrologia, Università degli Studi Federico II, Napoli
Luigi Russo Cattedra di Nefrologia, Università degli Studi Federico II, Napoli
Francesca Santoboni U.O.C. Nefrologia e Dialisi, Ospedale Parodi-Delfino, Colleferro (RM)
Claudio Ronco International Renal Research Institute, Ospedale S. Bortolo, Vicenza

DOI:

https://doi.org/10.33393/gcnd.2016.750

Keywords:

Chronic kidney disease (CKD), Observational studies, Randomized-controlled trials (RCTs), Vitamin D, Vitamin D receptor (VDR)

Abstract

Vitamin D represents the precursor of calcitriol, crucial for bone and mineral metabolism. The high prevalence of vitamin D deficiency and the detection of vitamin D receptor (VDR) both in the heart and vessels have focused the interest on potential cardiovascular effects of vitamin D. Although several experimental data showed the protective role of vitamin D, on the other hand vitamin D “overdose” can contribute to heart and vascular calcification. Meta-analyses of randomized-controlled trials (RCTs) underlined the association of vitamin D deficiency and increased cardiovascular morbidity and mortality but no significant improvements on cardiovascular outcomes are provided by the supplementation of vitamin D. The following review provides an update on pathophysiology of vitamin D and vitamin D receptor (VDR) discussing on the association with cardiovascular risk factors and disease and on the role of vitamin D supplementation in preventing cardiovascular disease in chronic kidney disease (CKD) patients. (Cardionephrology)