SARS-CoV-2 associated nephropathy: what we know so far

Authors

  • Aris Tsalouchos Azienda Usl Toscana Centro, S.O.S. Nefrologia e Dialisi, Ospedale SS. Cosma e Damiano, Pescia, Pistoia - Italia
  • Maurizio Salvadori Professore di Nefrologia, già Direttore Nefrologia e Trapianto, Azienda Ospedaliera Careggi, Firenze - Italia

DOI:

https://doi.org/10.33393/gcnd.2020.2166

Keywords:

APOL1-SARS-CoV2- associated nephropathy, SARS-CoV-2, SARS-CoV-2-associated nephropathy

Abstract

Acute kidney injury (AKI) is a frequent complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributable to i) hypotension and decreased kidney perfusion secondary to hemodynamic or hemostatic factors, ii) drug-induced nephrotoxicity, iii) cytokine storm syndrome related to sepsis. However: i) early new-onset proteinuria and hematuria in many patients, ii) the identification of SARS-CoV-2 viral load in precisely defined kidney compartments, iii) ultrastructural evidence of direct viral infection of the kidneys, and most importantly, iv) morphological alterations associated to cytopathic action induced by the virus support the existence of SARS-CoV-2 associated nephropathy. In addition, collapsing glomerulopathy reported in African American patients with underlying APOL1 kidney risk alleles and SARS-CoV-2 infection is the evidence of a distinct form of SARS-CoV-2 associated nephropathy, the APOL1-SARS-CoV2-associated nephropathy.

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References

Pneumonia of unknown cause – China. Disease outbreak news, World Health Organization, 5 January 2020. Available at: https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/. Accessed April 27, 2020.

L’Organizzazione Mondiale della Sanità dichiara il coronavirus pandemia. http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioNotizieNuovoCoronavirus.jsp?lingua=italiano&menu=notizie&p=dalministero&id=4209. Accessed April 27, 2020.

Covid-19 – Situazione nel mondo. http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioContenutiNuovoCoronavirus.jsp?lingua=italiano&id=5338&area=nuovoCoronavirus&menu=vuoto. Accessed June 11, 2020.

Corman VM, Muth D, Niemeyer D, et al. Hosts and Sources of Endemic Human Coronaviruses. Adv Virus Res. 2018;100:163‐88.

Sun P, Lu X, Xu C, et al. Understanding of COVID-19 based on current evidence, published online ahead of print, 2020 Feb 25. J Med Virol. 2020;10.1002/jmv.25722.

Andersen KG, Rambaut A, Lipkin WI, et al. The proximal origin of SARS-CoV-2. Nat Med. 2020;26(4):450‐2.

Miller R, Englund K. Transmission and risk factors of COVID-19, published online ahead of print, 2020 May 14. Cleve Clin J Med. 2020;10.3949/ccjm.87a.ccc029.

Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens, published online ahead of print, 2020 Mar 11. JAMA. 2020;323(18):1843‐4.

Vischini G, D’Alonzo S, Grandaliano G, et al. SARS-CoV-2 in the peritoneal waste in a patient treated with peritoneal dialysis, published online ahead of print, 2020 May 12. Kidney Int. 2020;S0085-2538(20):30531-7.

Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708‐20.

Lauer SA, Grantz KH, Bi Q, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172(9):577‐82.

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention, published online ahead of print, 2020 Feb 24. JAMA. 2020;10.1001/jama.2020.2648.

Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China, published online ahead of print, 2020 Feb 7. JAMA. 2020;323(11):1061‐9.

Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, published correction appears in Lancet. 2020 Jan 30. Lancet. 2020;395(10223):497‐506.

Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science. 2020;368(6490):473‐4.

Puelles VG, Lütgehetmann M, Lindenmeyer MT, et al. Multiorgan and Renal Tropism of SARS-CoV-2, published online ahead of print, 2020 May 13. N Engl J Med. 2020;NEJMc2011400. doi:10.1056/NEJMc2011400.

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507‐13.

Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829‐38.

Li Z, Wu M, Guo J, et al. Caution on kidney dysfunctions of 2019-nCoV patients. medRxiv 2020.02.08.20021212. Accessed March 2, 2020.

Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalized with COVID-19, published online ahead of print, 2020 May 16. Kidney Int. 2020;S0085-2538(20)30532-9.

Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179‐84.

Vaduganathan M, Vardeny O, Michel T, et al. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. 2020;382(17):1653‐9.

Naicker S, Yang CW, Hwang SJ, et al. The Novel Coronavirus 2019 epidemic and kidneys. Kidney Int. 2020;97(5):824‐8.

Batlle D, Soler MJ, Sparks MA, et al. Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology, published online ahead of print, 2020 May 4. J Am Soc Nephrol. 2020;ASN.2020040419.

Hong Xw, Chi Zp, Liu Gy, et al. Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection. MedRxiv. 2020. doi: 10.1101/2020.03.07.20032599. Accessed May 25, 2020.

Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270-3.

Gross O, Moerer O, Weber M, et al. COVID-19-associated nephritis: early warning for disease severity and complications? Lancet. 2020;395(10236):e87‐8.

Wan Y, Shang J, Graham R, et al. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020;94(7):e00127-20.

Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631‐7.

Guo L, Yu K, Li D, et al. Potential Pathogenesis of Multiple Organ Injury in COVID-19. Preprints 2020. doi: 10.20944/preprints202003.0308.v1.

Serfozo P, Wysocki J, Gulua G, et al. Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent. Hypertension. 2020;75(1):173‐82.

Ye M, Wysocki J, William J, et al. Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol. 2006;17(11):3067‐75.

Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271‐80.e8.

Matsuyama S, Ujike M, Morikawa S, et al. Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection. Proc Natl Acad Sci U S A. 2005;102(35):12543‐7.

Shulla A, Heald-Sargent T, Subramanya G, et al. A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. J Virol. 2011;85(2):873‐82.

Wu H, Uchimura K, Donnelly EL, et al. Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Cell Stem Cell. 2018;23(6):869‐81.e8.

Wilson PC, Wu H, Kirita Y, et al. The single-cell transcriptomic landscape of early human diabetic nephropathy. Proc Natl Acad Sci U S A. 2019;116(39):19619‐25.

Walls AC, Park YJ, Tortorici MA, et al. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181(2):281‐92.e6.

Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417‐8.

Kissling S, Rotman S, Gerber C, et al. Collapsing glomerulopathy in a COVID-19 patient, published online ahead of print, 2020 Apr 15. Kidney Int. 2020;S0085-2538(20)30395-1.

Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 2020; 98:219-27.

Farkash EA, Wilson AM, Jentzen JM. Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2, published online ahead of print, 2020 May 5. J Am Soc Nephrol. 2020;ASN.2020040432.

Pan XW, Xu D, Zhang H, et al. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis, published online ahead of print, 2020 Mar 31. Intensive Care Med. 2020;1‐3.

Diao B, Wang C, Wang R, et al. Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. medRxiv 2020.03.04.20031120. Accessed April 25, 2020.

Noris M, Benigni A, Remuzzi G. The case of Complement activation in COVID-19 multiorgan impact, published online ahead of print, 2020 May 24. Kidney Int. 2020;S0085-2538(20):30556-1.

Jhaveri KD, Meir LR, Flores Chang BS, et al. Thrombotic microangiopathy in a patient with COVID-19. Kidney International (2020), doi: https://doi.org/10.1016/j.kint.2020.05.025.

Larsen CP, Bourne TD, Wilson JD, et al. Collapsing Glomerulopathy in a Patient With Coronavirus Disease 2019 (COVID-19), published online ahead of print, 2020 Apr 9. Kidney Int Rep. 2020;5(6):935‐9.

Peleg Y, Kudose S, D’Agati V, et al. Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection, published online ahead of print, 2020 Apr 28. Kidney Int Rep. 2020;5(6):940‐5.

Freedman BI, Limou S, Ma L, Kopp JB. APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD. Am J Kidney Dis. 2018;72(5 Suppl. 1):S8‐16.

Published

2020-07-08

How to Cite

Tsalouchos, A., & Salvadori, M. (2020). SARS-CoV-2 associated nephropathy: what we know so far. Giornale Di Clinica Nefrologica E Dialisi, 32(1), 102–106. https://doi.org/10.33393/gcnd.2020.2166
Received 2020-06-14
Accepted 2020-06-16
Published 2020-07-08

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