Therapeutic Perspectives in the Treatment of Addison's Disease

Abstract

Innovative therapeutic applications that could lead to a new and different approach for the treatment of Addison's disease are considered and evaluated in this editorial. Even though the information on Addison's disease is still limited, mostly due to its rarity, the main pathogenetic mechanisms of the disease are here discussed as to explore potential future strategies for the treatment of this pathology. This editorial analyzes the genetic and immunological factors in Addison's disease, and tries to understand which could be the role of the adrenocortical stem cells for the regeneration of the glandular functions. At the end, after two clinical trials are pointed out, the editorial puts forward the hypothesis of some therapeutic possibilities that could open new perspectives on how to treat patients affected by this autoimmune disease.