Phosphate Balance and Organ Damage

Abstract

Numerous in vitro and clinical studies support the notion that phosphate and mineral bone metabolism abnormalities (known as chronic kidney diseas-emineral and bone disorder, CKD-MBD) are closely associated with cardiovascular as well as bone diseases in CKD. Although the natural history and pathophysiology of mineral metabolism derangements are yet to be elucidated, it is widely accepted that the link between CKD-MBD and vascular calcification may explain the astonishing risk of unfavorable outcome connected to CKD-MBD. In this brief review article, we summarize the large existing body of evidence supporting the association between phosphate metabolism and organ damage as well as survival in CKD.