Cost per responder for upadacitinib vs abatacept in patients with moderate-to-severe Rheumatoid Arthritis in Italy

Authors

  • Roberto Caporali Department of Clinical and Community Science (DISCCO), University of Milan and Department of Rheumatology and Medical Science , ASST Pini-COT, Milan - Italy
  • Roberto Ravasio Market Access Provider, Milan - Italy
  • Paola Raimondo Market Access Provider, Milan - Italy
  • Fausto Salaffi Rheumatology Clinic, “Carlo Urbani” Hospital, Department of Clinical and Molecular Science, Università Politecnica delle Marche, Jesi (AN) - Italy

DOI:

https://doi.org/10.33393/grhta.2021.2267

Keywords:

Abatacept, Cost per responder, Italian NHS, Rheumatoid Arthritis, Upadacitinib

Abstract

Purpose: The objective of this economic evaluation was to compare the cost per responder between upadacitinib and abatacept (intravenous [iv] or subcutaneous [sc]) in patients with moderate-to-severe Rheumatoid Arthritis (RA) in Italy.

Methods: The clinical efficacy was assessed based on SELECT-CHOICE study results. The clinical efficacy of upadacitinib and abatacept (iv or sc) was measured by Clinical Remission (CR), Low Disease Activity (LDA) and American College of Rheumatology response (ACR20, 50 and 70). The treatment cost was based on the number of administrations dispensed at 12 or 24 weeks. The cost per responder was adopted as a cost-effectiveness indicator.

Results: Independent of the clinical efficacy measure used and the duration of treatment considered, the cost per responder was consistently lower for upadacitinib compared to abatacept (iv or sc) across all clinical measures. For example, considering the CR at 24 weeks, the cost per responder for upadacitinib was € 9,417 compared to € 17,817 for abatacept sc or to € 23,110 for abatacept iv. The differences in the cost per responder between upadacitinib and abatacept (iv or sc) increased when higher ACR response levels were considered.

Conclusions: These results suggested that upadacitinib is a cost-effectiveness option compared to abatacept (iv or sc) from the perspective of the Italian National Health Service in patients with moderate-to-severe Rheumatoid Arthritis in Italy.

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Published

2021-07-12

How to Cite

1.
Caporali R, Ravasio R, Raimondo P, Salaffi F. Cost per responder for upadacitinib vs abatacept in patients with moderate-to-severe Rheumatoid Arthritis in Italy. Grhta [Internet]. 2021 Jul. 12 [cited 2021 Jul. 28];8:69-7. Available from: https://journals.aboutscience.eu/index.php/grhta/article/view/2267

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Original Research Article

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