The importance of the Covid-19 vaccine in patients suffering from adult autosomal dominant polycystic kidney disease (ADPKD)
DOI:
https://doi.org/10.33393/gcnd.2021.2256Keywords:
ADPKD patients, SARS-CoV-2 (Covid-19), VaccineAbstract
The SARS-CoV-2 (Covid-19) infection affected about 106 million people worldwide and the total amount of casualties now sits at a staggering 2 millions.
Chronic Kidney Disease (CKD) emerged as the first risk factor in worst patients, not considering old age. Kidney disease and acute kidney injury have been correlated with a higher chance of death. This combination of CKD and higher Covid-19 related mortality requires immediate response from a prevention point of view at first and then from a therapeutic one.
There is not a clear relation between Covid-19 and ADPKD. What can be inferred is the following: Covid uses the ACE2 receptors on cell membranes to “lock on” its target. It is well-established in fact that the RAAS is more active in ADPKD patients and it may represent an additional risk factor for these patients.
At the moment three Covid-19 vaccines have been approved, and two of them have been already administered, such as Pfizer BioNTech and Moderna, sharing the same mechanism. AstraZeneca released a third option. All of them are completely safe and reliable, each one with its own feature.
Therefore, considering how delicate ADPKD patients are, vaccination is strongly recommended.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Accepted 2021-03-06
Published 2021-07-13
