Pregnancy and Oxidative Stress
DOI:
https://doi.org/10.33393/gcnd.2013.1035Keywords:
Pre-eclampsia, Pregnancy, Oxidative stressAbstract
Pre-eclampsia is a relatively common complication of pregnancy, interesting about a 3% of the pregnancies. Its pathogenesis has been not yet completely clarified. However, a maternal endothelial dysfunction, particularly at the placenta level, seem to be the key factor in the development of this disease that clinically involves many organs such as kidney, brain and liver, characterized by hypertension, proteinuria and oedema. Recent works suggest a pathogenetic role of an altered expression of placental anti-angiogenic factors with consequent modifications in the redox state resulting in an oxidative stress. The effects to these anti-angiogenic factors results in a systemic endothelial dysfunction with hypertension, proteinuria, and the other systemic manifestations, such as encelophalopathy. Here, we will describe the most recent insights into the pathophysiology of preeclampsia attempting to provide a unifying hypothesis to reconcile the abnormalities at the feto-placental level and the clinical features of the maternal syndrome and provide a rationale for potential future prophylactic and therapeutic interventions for this pregnancy complication.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2013 The authors
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors contributing to Giornale di Clinica Nefrologica e Dialisi (GCND) agree to publish their articles under the CC-BY-NC 4.0 license, which allows third parties to re-use the work without permission as long as the work is properly referenced and the use is non-commercial.