Effectiveness of periodontal intervention on the levels of N-terminal pro-brain natriuretic peptide in chronic periodontitis patients

Ibrahim Fazal; Bhavya Shetty; Umesh Yadalam; Safiya Fatima Khan; Manjusha Nambiar

doi:10.33393/jcb.2022.2454

Authors

Ibrahim Fazal Department of Periodontology, Faculty of Dental Sciences, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka - India https://orcid.org/0000-0003-1618-883X
Bhavya Shetty Department of Periodontology, Faculty of Dental Sciences, M. S. Ramaiah University of Applied Sciences, Bangalore, Karnataka - India https://orcid.org/0000-0001-8701-3864
Umesh Yadalam Department of Periodontology, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India https://orcid.org/0000-0002-0362-6143
Safiya Fatima Khan Department of Periodontology, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India https://orcid.org/0000-0003-4117-128X
Manjusha Nambiar Department of Periodontology, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India

DOI:

https://doi.org/10.33393/jcb.2022.2454

Keywords:

Brain natriuretic peptide, Cardiovascular biomarker, Nonsurgical periodontal therapy, NT-proBNP, Periodontal disease

Abstract

Background: N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an inactive hormone that is seen during inflammation and is a known biomarker of cardiovascular disease (CVD). Evidence suggests that periodontitis has a bidirectional relationship with CVD and NT-proBNP has a potential role in periodontal disease. However, there is no evidence on the impact of nonsurgical periodontal therapy (NSPT) on the levels of NT-proBNP in gingival crevicular fluid (GCF) and serum in patients with chronic periodontitis. Hence, the aim of this study was to compare the levels of NT-proBNP in GCF and serum in patients with chronic generalized periodontitis.

Materials and methods: GCF and serum samples were collected in 19 patients with chronic periodontitis before and after NSPT after 6 weeks and the cumulative or reduction in values of NT-proBNP in GCF and serum was assessed. NT-proBNP levels in GCF and serum were determined by enzyme-linked immunosorbent assay.

Results: The concentrations of NT-proBNP were significantly reduced in GCF and serum after NSPT. Statistically significant difference of NT-proBNP concentration between pre- and postgroups in GCF was apparent (p < 0.0001), whereas statistically nonsignificant results in NT-proBNP serum levels when compared at baseline to postoperative state with mean of 61.77 (22.6 standard deviation [SD]) preoperatively and 72.67 (51.86 SD) postoperatively (p = 0.0007) was observed.

Conclusion: Significant reduction of NT-proBNP concentrations in GCF and serum in patients with chronic periodontitis subjected to NSPT was observed. This may account for a significant relation between periodontal disease, bacteremia, and CVD.

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