Diffusion-weighted magnetic resonance imaging (DWI) for quantifying cyst volume and characterizing non-cystic tissue in polycystic kidney disease: the Mario Negri experience

Autori

  • Ariela Benigni Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo - Italy

DOI:

https://doi.org/10.33393/gcnd.2023.2599

Parole chiave:

Cysts, Fibrosis, Diffusion magnetic resonance imaging, Polycystic kidney disease

Abstract

Beyond total kidney and cyst volume, non-cystic tissue plays an important role in autosomal dominant polycystic kidney disease (ADPKD) progression. Recent advancements in magnetic resonance imaging (MRI) offer the possibility to study kidney microstructure and function, beyond anatomy. In particular, Diffusion Weighted Imaging (DWI), a MRI technique sensitive to water molecule motion (diffusion) in biological tissues, allows to investigate microstructure. This study, recently published in the European Radiology scientific journal, proposes and preliminary validates a novel method to segment cystic and non-cystic volume on DWI scans from ADPKD patients. The study also provides evidence of DWI potential in characterizing non-cystic kidney tissue, denoted by higher diffusion and lower perfusion than healthy tissue, in line with its fibrotic nature and the likely presence of microcysts. Overall, this study provides evidence in support of DWI potential in ADPKD. DWI could complement existing biomarkers for noninvasively staging, monitoring, and predicting ADPKD progression and evaluating the impact of novel therapies, possibly targeting damaged non-cystic tissue besides cyst expansion.

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Riferimenti bibliografici

Caroli A, Villa G, Brambilla P, et al. Diffusion magnetic resonance imaging for kidney cyst volume quantification and non-cystic tissue characterisation in ADPKD. Eur Radiol. 2023 Epub ahead of print. https://doi.org/10.1007/s00330-023-09601-4. https://pubmed.ncbi.nlm.nih.gov/37017703/ DOI: https://doi.org/10.1007/s00330-023-09601-4

Pubblicato

2023-06-30

Come citare

1.
Benigni A. Diffusion-weighted magnetic resonance imaging (DWI) for quantifying cyst volume and characterizing non-cystic tissue in polycystic kidney disease: the Mario Negri experience. G Clin Nefrol Dial [Internet]. 30 giugno 2023 [citato 23 settembre 2023];35(1):34-5. Available at: https://journals.aboutscience.eu/index.php/gcnd/article/view/2599

Fascicolo

Sezione

Il rene policistico - In collaborazione con AIRP

Categorie

Received 2023-05-02
Accepted 2023-05-02
Published 2023-06-30