PKD: Biomolecular Aspects
DOI:
https://doi.org/10.33393/gcnd.2012.1182Keywords:
ADPKD, Cyst initiation, Tubular cell proliferationAbstract
Autosomal dominant polycystic kidney disease (ADPKD)is the most common genetic kidney disease with an estimated prevalence of between 1:400 and 1:1,000. Caused by germline mutations in PKD1 (85%) or PKD2 (15%). The cardinal feature of ADPKD is the presence of multiple fluid-filled kidney cysts which enlarge over time. Cyst initiation and expansion is a complex process characterized by abnormalities in tubular cell proliferation, fluid secretion, extracellular matrix formation and cell polarity. Currently, the three major treatment strategies are to: 1) reduce cAMP levels; 2) inhibit cell proliferation, and 3) reduce fluid secretion.Downloads
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Published
2018-01-26
How to Cite
Scolozzi, C. (2018). PKD: Biomolecular Aspects. Giornale Di Clinica Nefrologica E Dialisi, 24(4), 92–94. https://doi.org/10.33393/gcnd.2012.1182
Issue
Section
Polycystic kidney disease - In collaboration with AIRP
License
Authors contributing to Giornale di Clinica Nefrologica e Dialisi (GCND) agree to publish their articles under the CC-BY-NC 4.0 license, which allows third parties to re-use the work without permission as long as the work is properly referenced and the use is non-commercial.