Use and Safety of Anthroposophic Medications for Acute Respiratory and Ear Infections: A Prospective Cohort Study

  • Harald J. Hamre Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.
  • Anja Glockmann Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.
  • Michael Fischer ClinResearch GmbH, Cologne, Germany.
  • David S. Riley University of New Mexico School of Medicine, Santa Fe, New Mexico, U.S.A.
  • Erik Baars Louis Bolk Instituut, Driebergen, The Netherlands.
  • Helmut Kiene Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.
Keywords: Adverse effects, complementary therapies, drug monitoring, otitis media, respiratory tract infections

Abstract

Objective: Anthroposophic medications (AMED) are widely used, but safety data on AMED from large prospective studies are sparse. The objective of this analysis was to determine the frequency of adverse drug reactions (ADR) to AMED in outpatients using AMED for acute respiratory and ear infections. Methods: A prospective four-week observational cohort study was conducted in 21 primary care practices in Europe and the U.S.A. The cohort comprised 715 consecutive outpatients aged ≥1 month, treated by anthroposophic physicians for acute otitis and respiratory infections. Physicians’ prescription data and patient reports of adverse events were analyzed. Main outcome measures were use of AMED and ADR to AMED. Results: Two patients had confirmed ADR to AMED: 1) swelling and redness at the injection site after subcutaneous injections of Prunus spinosa 5%, 2) sleeplessness after intake of Pneumodoron® 2 liquid. These ADR lasted one and two days respectively; both subsided after dose reduction; none were unexpected; none were serious. The frequency of confirmed ADR to AMED was 0.61% (2/327) of all different AMED used, 0.28% (2/715) of patients, and 0.004% (3/73,443) of applications. Conclusion: In this prospective study, anthroposophic medications used by primary care patients with acute respiratory or ear infections were well tolerated. Abbreviations: A-: anthroposophy; ADR: adverse drug reactions; AE: adverse events; AM: anthroposophic medicine; AMED: AM medication; C-: conventional; ENE-patients: eligible, not enrolled patients; IIPCOS: International Primary Care Outcomes Study
Published
2007-01-01
How to Cite
HamreH. J., GlockmannA., FischerM., RileyD. S., BaarsE., & KieneH. (2007). Use and Safety of Anthroposophic Medications for Acute Respiratory and Ear Infections: A Prospective Cohort Study. Drug Target Insights, 2(1). https://doi.org/10.33393/dti.2007.1302
Section
Original Research Article