Association between cardiovascular diseases and periodontal disease: more than what meets the eye


  • Bhavya Shetty Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Ibrahim Fazal Department of Periodontics, Faculty Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Safiya Fatima Khan Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India
  • Manjusha Nambiar Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India
  • Khadijathul Irfana D Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Rohit Prasad Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Akshata Raj Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India



Cardiovascular diseases, Periodontal disease, Periodontal therapy, Risk factor, Systematic review, Systemic diseases


Cardiovascular diseases (CVDs) are inflammatory diseases of coronary arteries accompanying atheroma formation that can spawn impairment and, in severe cases, death. CVDs are the leading cause of death in the world. In recent decades, investigators have focused their impact on CVD by periodontal disease (PD). PD is a risk factor that can trigger the formation, maturation, and instability of atheroma in the arteries. Two mechanisms have been proposed to explain this relationship: periodontopathic pathogens explicitly invade the circulation or indirectly increase systemic levels of inflammatory mediators. It has been suggested that improvement in disease state has a positive effect on others. This review summarizes evidence from epidemiological studies as well as researches focusing on potential causation channels to deliver a comprehensive representation of the relationship between PD and CVD.


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How to Cite

Shetty, B., Fazal, I., Khan, S. F., Nambiar, M., Irfana D, K., Prasad, R., & Raj, A. (2023). Association between cardiovascular diseases and periodontal disease: more than what meets the eye. Drug Target Insights, 17(1), 31–38.
Received 2022-10-25
Accepted 2022-11-10
Published 2023-02-02