Association between cardiovascular diseases and periodontal disease: more than what meets the eye


  • Bhavya Shetty Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Ibrahim Fazal Department of Periodontics, Faculty Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Safiya Fatima Khan Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India
  • Manjusha Nambiar Department of Periodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Bangalore, Karnataka - India
  • Khadijathul Irfana D Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Rohit Prasad Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India
  • Akshata Raj Department of Periodontics, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore, Karnataka - India



Cardiovascular diseases, Periodontal disease, Periodontal therapy, Risk factor, Systematic review, Systemic diseases


Cardiovascular diseases (CVDs) are inflammatory diseases of coronary arteries accompanying atheroma formation that can spawn impairment and, in severe cases, death. CVDs are the leading cause of death in the world. In recent decades, investigators have focused their impact on CVD by periodontal disease (PD). PD is a risk factor that can trigger the formation, maturation, and instability of atheroma in the arteries. Two mechanisms have been proposed to explain this relationship: periodontopathic pathogens explicitly invade the circulation or indirectly increase systemic levels of inflammatory mediators. It has been suggested that improvement in disease state has a positive effect on others. This review summarizes evidence from epidemiological studies as well as researches focusing on potential causation channels to deliver a comprehensive representation of the relationship between PD and CVD.


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Libby P, Buring JE, Badimon L, et al. Atherosclerosis. Nat Rev Dis Primers. 2019;5:56. DOI:

Nesse W, Dijkstra PU, Abbas F, et al. Increased prevalence of cardiovascular and autoimmune diseases in periodontitis patients: a cross‐sectional study. JPeriodontol. 2010 Nov;81(11):1622-1628. DOI:

Sanz M, Del Castillo AM, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report. JClinPeriodontol. 2020 Mar 1;47(3):268-288. DOI:

Wu T, Trevisan M, Genco RJ, Dorn JP, Falkner KL, Sempos CT. Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study.Arch Intern Med.2000;160:2749-2755. DOI:

Khader YS, Albashaireh ZS, Alonari MA. Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: a meta-analysis.J Periodontol.2004;75:1046-1053. DOI:

Ford PJ, Gemmell E, Chan A, et al. Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study. Oral Microbiol Immunol. 2006;21:206-211. doi: 10.1111/j.1399-302X.2006.00276.x. DOI:

Nakano K, Nemoto H, Nomura R, et al. Detection of oral bacteria in cardiovascular specimens. Oral Microbiol Immunol. 2009;24:64-68. doi: 10.1111/j.1399-302X.2008.00479.x. DOI:

Pucar A, Milasin J, Lekovic V, et al. Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. J Periodontol. 2007;78:677-682. doi: 10.1902/jop.2007.060062. DOI:

Roth GA, Moser B, Huang SJ, et al. Infection with a periodontal pathogen induces procoagulant effects in human aortic endothelial cells. J Thromb Haemostasis. 2006;4:2256-2261. doi: 10.1111/j.1538-7836.2006.02128.x. DOI:

Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C‐reactive protein level. JPeriodontol. 2001 Sep;72(9):1221-1227. DOI:

Singh N, Chandel S, Singh H, Agrawal A, Savitha AN. Effect of scaling & root planing on the activity of ALP in GCF & serum of patients with gingivitis, chronic and aggressive periodontitis: a comparative study. JOral BiolCraniofacRes. 2017 May 1;7(2):123-126. DOI:

Delange N, Lindsay S, Lemus H, Finlayson TL, Kelley ST, Gottlieb RA. Periodontal disease and its connection to systemic biomarkers of cardiovascular disease in young American Indian/Alaskan natives. JPeriodontol. 2018 Feb;89(2):219-227. DOI:

Mohammed AA, Youssef JM, Metwally SS, Anees MM. Evaluation of the serum ceruloplasmin level before and after non-surgical periodontal therapy in patients with chronic periodontitis. Stomatological Dis Sci. 2018 Mar 14;2:3. DOI:

Ilea A, Lazăr AC, Roșca D, et al. Periodontitis in a group of patients with cardiovascular disease. Anatomy Physiol Biochem Int J. 2018;5(4):1-6.doi: 10.19080/APBIJ.2018.05.555668.

Leira Y, Blanco J. Brain natriuretic peptide serum levels in periodontitis. JPeriodontal Res. 2018 Aug;53(4):575-581. DOI:

Ameen M, Attia AM, Felimban A, et al. Evaluation of cardiac biomarkers in smokers and non-smokers with chronic periodontitis. Int J Health Sci. 2020 May;14(3):26.

Gupta M, Chaturvedi R, Jain A. Role of cardiovascular disease markers in periodontal infection: understanding the risk. Indian J Dent Res. 2015 May 1;26(3):231. DOI:

Boyapati R, Vudathaneni V, Nadella SB, Ramachandran R, Dhulipalla R, Adurty C. Mapping the link between cardiac biomarkers and chronic periodontitis: a clinico-biochemical study. J Indian Soc Periodontol. 2020 Jul;24(4):309. DOI:

Fazal I, Shetty B, Yadalam U, Khan SF, Nambiar M. Effectiveness of periodontal intervention on the levels of N-terminal pro-brain natriuretic peptide in chronic periodontitis patients. J Circ Biomark. 2022 Oct 3;11:48-56. DOI:

Genco RJ, Wu T, Grossi S, Faulkner K, Zambon JJ, Trevisan M. Periodontal microflora related to the risk of myocardial infarction: a case-control study (abstract 2811). J Dent Res 1999;78(special issue):457.

Arbes SJ, Slade GD, Beck J. Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. J Dent Res 1999;78:1777-1782. DOI:

DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality.BMJ.1993;306:688-691. DOI:

Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease.J Periodontol.1996;67:1123-1137. DOI:

Hujoel P, Drangsholt M, Spiekerman C, DeRouen T. Periodontal disease and coronary heart disease risk. JAMA. 2000;284:1406-1410. DOI:

Joshipura KJ, Rimm EB, Douglass CW, Trichopoulos D, Ascherio A, Willett WC. Poor oral health and coronary heart disease. J Dent Res 1996;75:1631-1636. DOI:

Howell TH, Ridker PM, Ajani UA, Hennekens CH, Christen WG. Periodontal disease and risk of subsequent cardiovascular disease in U.S. male physicians. J Am Coll Cardiol. 2001;37:445-450. DOI:

Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease and stroke: a systematic review.Ann Periodontol.2003;8:38-53. DOI:

Janket SJ, Baird AE, Chuang SK, Jones JA. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2003;95:559-569. DOI:

Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies.Int Dent J.2009;59:197-209.

Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting meta-analysis of observational studies in epidemiology (MOOSE) group.JAMA.2000;283:2008-2012. DOI:

Caúla AL, Lira-Junior R, Tinoco EM, Fischer RG. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol. 2014;41:875-882. doi: 10.1111/jcpe.12290. DOI:

Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol. 2013;40:681-687. doi: 10.1111/jcpe. 12110. DOI:

Bresolin AC, Pronsatti MM, Pasqualotto LN, et al. Lipid profiles and inflammatory markers after periodontal treatment in children with congenital heart disease and at risk for atherosclerosis. Vasc Health Risk Manage. 2013;9:703-709. doi: 10.2147/VHRM.S52187. DOI:

Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551-2567. doi: 10.1093/eurheartj/ehs184. DOI:

Bokhari SA, Khan AA, Butt AK, et al. Nonsurgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol. 2012;39:1065-1074. doi: 10.1111/j.1600-051X.2012.01942.x 128. DOI:

Banthia R, Jain P, Banthia P, Belludi S, Parwani S, Jain A. Effect of phase I periodontal therapy on pro-coagulant state in chronic periodontitis patients– a clinical and haematological study. J Irish Dental Assoc. 2013;59:183-188.

Kiany F, Hedayati A. Evaluation of serum anti-cardiolipin antibodies after non-surgical periodontal treatment in chronic periodontitis patients. Odontology. 2015;103:203-209. doi: 10.1007/s10266-014-0149-2. DOI:

Gupta B, Sawhney A, Patil N, et al. Effect of surgical periodontal therapy on serum C-reactive protein levels using ELISA in both chronic and aggressive periodontitis patient. J Clin Diagnostic Res. 2015;9:Zc01-Zc05. doi: 10.7860/JCDR/2015/14680.6558. DOI:

Graziani F, Cei S, Orlandi M, et al. Acute-phase response following full-mouth versus quadrant non-surgical periodontal treatment: a randomized clinical trial. J Clin Periodontol. 2015;42:843-852. doi: 10.1111/jcpe.12451 132. DOI:

Houcken W, Teeuw WJ, Bizzarro S, et al. Arterial stiffness in periodontitis patients and controls. A case-control and pilot intervention study. J Hum Hypertens. 2016;30:24-29. doi: 10.1038/jhh.2015.41. DOI:

Torumtay G, Kirzioglu FY, Öztürk Tonguç M, Kale B, Calapoglu M, Orhan H. Effects of periodontal treatment on inflammation and oxidative stress markers in patients with metabolic syndrome. J Periodontal Res. 2016;51:489-498. doi: 10.1111/jre.12328 134. DOI:

Siddeshappa ST, Nagdeve S, Yeltiwar RK, Parvez H, Deonani S, Diwan V. Evaluation of various hematological parameters in patients with periodontitis after nonsurgical therapy at different intervals. J Indian Soc Periodontol. 2016;20:180-183. doi: 10.4103/0972-124X.175172 135. DOI:

Arvanitidis E, Bizzarro S, Alvarez Rodriguez E, Loos BG, Nicu EA. Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy. Thromb J. 2017;15:5. doi: 10.1186/s12959-016-0125-x 136. DOI:

Zhou QB, Xia WH, Ren J, et al. Effect of intensive periodontal therapy on blood pressure and endothelial microparticles in patients with prehypertension and periodontitis: a randomized controlled trial. J Periodontol. 2017;88:711-722. doi: 10.1902/jop.2017.160447 137. DOI:

de Souza AB, Okawa RT, Silva CO, Araújo MG. Short-term changes on C-reactive protein (CRP) levels after non-surgical periodontal treatment in systemically healthy individuals. Clin Oral Investig. 2017;21:477-484. doi: 10.1007/s00784-016-1817-0. DOI:

Jockel-Schneider Y, Bechtold M, Haubitz I, et al. Impact of anti-infective periodontal therapy on parameters of vascular health. J Clin Periodontol. 2018;45:354-363. doi: 10.1111/jcpe. 12849 139. DOI:

Saffi MAL, Rabelo-Silva ER, Polanczyk CA, et al. Periodontal therapy and endothelial function in coronary artery disease: a randomized controlled trial. Oral Dis. (2018) 24:1349-1357. doi: 10.1111/odi.12909 140. DOI:

Morozumi T, Yashima A, Gomi K, et al. Increased systemic levels of inflammatory mediators following one-stage full-mouth scaling and root planing. J Periodontal Res. 2018;53:536-544. doi: 10.1111/jre.12543 141. DOI:

Moeintaghavi A, Arab HR, Moghaddam MA, Shahmohammadi R, Bardan BY, Soroush Z. Evaluation of effect of surgical and nonsurgical periodontal therapy on serum C-reactive protein, triglyceride, cholesterol, serum lipoproteins and fasting blood sugar in patients with severe chronic periodontitis. Open Dent J. 2019;13:15-21. doi: 10.2174/1874210601913010015. DOI:

Herrera D, Molina A, Buhlin K, Klinge B. Periodontal diseases and association with atherosclerotic disease. Periodontology 2000. 2020;83:66-89. doi: 10.1111/prd.12302. DOI:

Tonetti MS, D’Aiuto F, Nibali L, et al. Treatment of periodontitis and endothelial function. N Engl J Med. 2007;356:911-920. doi: 10.1056/NEJMoa063186 143. DOI:

Teeuw WJ, Slot DE, Susanto H, et al. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol. 2014;41:70-79. doi: 10.1111/jcpe.12171 144. DOI:

D’Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res. 2005;84:269-273. doi: 10.1177/154405910508400312 145. DOI:

D’Aiuto F, Parkar M, Nibali L, Suvan J, Lessem J, Tonetti MS. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am Heart J. 2006;151:977-984. doi: 10.1016/j.ahj.2005.06.018. DOI:

Piconi S, Trabattoni D, Luraghi C, et al. Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. FASEB J. 2009;23:1196-1204. doi: 10.1096/fj.08-119578. DOI:

Reyes L, Herrera D, Kozarov E, Roldán S, Progulske-Fox A. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Clin Periodontol. 2013;40(Suppl.)14:S30-S50. doi: 10.1111/jcpe.12079. DOI:

Kebschull M, Demmer RT, Papapanou PN. “Gum bug, leave my heart alone!”–epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J Dental Res. 2010;89:879-902. doi: 10.1177/0022034510375281. DOI:

Joshipura K, Zevallos JC, Ritchie CS. Strength of evidence relating periodontal disease and atherosclerotic disease. Compend Contin Educ Dent. 2009;30:430-439.

Ross R. Atherosclerosis is an inflammatory disease. Am Heart J. 1999;138:S419-S420. doi: 10.1016/S0002-8703(99)70266-8. DOI:

Ratto-Tespestini A, Chaparro PJ, Romito G, et al. Comparison of independent and dependent culture methods for the detection of transient bacteremia in diabetic subjects with chronic periodontitis. Biomédica Revista del Instituto Nacional de Salud. 2016;36:156-161. doi: 10.7705/biomedica.v36i1.2674. DOI:

Balejo RDP, Cortelli JR, Costa FO, et al. Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial. J Appl Oral Sci. 2017;25:586-595. doi: 10.1590/1678-7757-2017-0112. DOI:

Dhotre S, Jahagirdar V, Suryawanshi N, Davane M, Patil R, Nagoba B. Assessment of periodontitis and its role in viridans streptococcal bacteremia and infective endocarditis. Indian Heart J. 2018;70:225-232. doi: 10.1016/j.ihj.2017.06.019 81. DOI:

Horliana ACRT, Chambrone L, Foz AM, et al. Dissemination of periodontal pathogens in the bloodstream after periodontal procedures: a systematic review. PLoS One. 2014;9:e98271. doi: 10.1371/journal.pone.0098271. DOI:

Figuero E, Sánchez-Beltrán M, Cuesta-Frechoso S, et al. Detection of periodontal bacteria in atheromatous plaque by nested polymerase chain reaction. J Periodontol. 2011;82:1469-1477. doi: 10.1902/jop.2011.100719. DOI:

Figuero E, Lindahl C, Marín MJ, et al. Quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. J Periodontol. 2014;85:1182-1193. doi: 10.1902/jop.2014.130604. DOI:

Serra e Silva Filho W, Casarin RC, Nicolela EL Jr, et al. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One. 2014;9:e109761. doi: 10.1371/journal.pone.0109761. DOI:

Armingohar Z, Jørgensen JJ, Kristoffersen AK, Abesha-Belay E, Olsen I. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microbiol. 2014;6:1-13. doi: 10.3402/jom.v6.23408. DOI:

Rafferty B, Jönsson D, Kalachikov S, et al. Impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. J Internal Med. 2011;270:273-280. doi: 10.1111/j.1365-2796.2011.02373.x. DOI:

Kozarov EV, Dorn BR, Shelburne CE, Dunn WA Jr, Progulske-Fox A. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscleros Thromb Vasc Biol. 2005;25:e17-e18. doi: 10.1161/01.ATV.0000155018.67835.1a. DOI:

Deshpande RG, Khan MB, Genco CA. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun. 1998;66:5337-5343. doi: 10.1128/IAI.66.11.5337-5343.1998. DOI:

Dorn BR, Dunn WA Jr, Progulske-Fox A. Invasion of human coronary artery cells by periodontal pathogens. Infect Immun. 1999;67:5792-5798. doi: 10.1128/IAI.67.11.5792-5798.1999. DOI:

Olsen I, Progulske-Fox A. Invasion of Porphyromonas gingivalis strains into vascular cells and tissue. J Oral Microbiol. 2015;7:28788. doi: 10.3402/jom.v7.28788. DOI:

Gibson FC III, Hong C, Chou HH, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801-2806. doi: 10.1161/01.CIR.0000129769.17895.F0. DOI:

Jain A, Batista EL Jr, Serhan C, Stahl GL, Van Dyke TE. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun. 2003;71:6012-6018. doi: 10.1128/IAI.71.10.6012-6018.2003. DOI:

Brodala N, Merricks EP, Bellinger DA, et al. Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. Arterioscleros Thromb Vasc Biol. 2005;25:1446-1451. Doi: 10.1161/01.ATV.0000167525.69400.9c. DOI:

Chukkapalli SS, Velsko IM, Rivera-Kweh MF, Zheng D, Lucas AR, Kesavalu L. Polymicrobial oral infection with four periodontal bacteria orchestrates a distinct inflammatory response and atherosclerosis in ApoE null Mice. PloS One. 2015;10:e0143291. doi: 10.1371/journal.pone.0143291. DOI:

Velsko IM, Chukkapalli SS, Rivera MF, et al. Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis. PLoS One. 2014;9:e97811. doi: 10.1371/journal.pone.0097811. DOI:

Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol. 2006;33:401-407. doi: 10.1111/j.1600-051X.2006.00924.x 83. DOI:

Lafaurie GI, Mayorga-Fayad I, Torres MF, et al. Periodontopathic microorganisms in peripheric blood after scaling and root planing. J Clin Periodontol. 2007;34:873-879. doi: 10.1111/j.1600-051X.2007.01125.x. DOI:

Pérez-Chaparro PJ, Gracieux P, Lafaurie GI, Donnio P-Y, Bonnaure-Mallet M. Genotypic characterization of Porphyromonas gingivalis isolated from subgingival plaque and blood sample in positive bacteremia subjects with periodontitis. J Clin Periodontol. 2008;35:748-753. doi: 10.1111/j.1600-051X.2008.01296.x. DOI:

Castillo DM, Sánchez-Beltrán MC, Castellanos JE, et al. Detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. J Clin Periodontol. 2011;38:418-427. doi: 10.1111/j.1600-051X.2011.01717.x. DOI:

Waghmare AS, Vhanmane PB, Savitha B, Chawla RL, Bagde HS. Bacteremia following scaling and root planing: a clinico-microbiological study. J Indian Soc Periodontol. 2013;17:725-730. doi: 10.4103/0972-124X.124480. DOI:

Sahrmann P, Manz A, Attin T, Zbinden R, Schmidlin PR. Effect of application of a PVP-iodine solution before and during subgingival ultrasonic instrumentation on post-treatment bacteraemia: a randomized single-centre placebo-controlled clinical trial. J Clin Periodontol. 2015;42:632-639. doi: 10.1111/jcpe.12416. DOI:

Marín MJ, Figuero E, González I, et al. Comparison of the detection of periodontal pathogens in bacteraemia after tooth brushing by culture and molecular techniques. Med Oral Patol Oral Cir Bucal. 2016;21:e276-e284. doi: 10.4317/medoral.20842. DOI:

Elkaïm R, Dahan M, Kocgozlu L, et al. Prevalence of periodontal pathogens in subgingival lesions, atherosclerotic plaques and healthy blood vessels: a preliminary study. J Periodontal Res. 2008;43:224-231. doi: 10.1111/j.1600-0765.2007.01018.x. DOI:

Gaetti-Jardim E, Marcelino SL, Feitosa ACR, Romito GA, Avila-Campos MJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol. 2009;58:1568-1575. doi: 10.1099/jmm.0.013383-0. DOI:

Lavigne SE, Forrest JL. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal disease and cardiovascular diseases: Position paper from the Canadian Dental Hygienists Association. CanJDentHyg. 2020 Feb;54(1):32.

Febbraio M, Roy CB, Levin L. Is there a causal link between periodontitis and cardiovascular disease? A concise review of recent findings. Int Dent J. 2022 Feb;72(1):37-51. doi: 10.1016/j.identj.2021.07.006. DOI:

Paul O, Arora P, Mayer M, Chatterjee S. Inflammation in periodontal disease: possible link to vascular disease. Frontiers Physiol. 2021 Jan 14;11:609614. DOI:

Larvin H, Kang J, Aggarwal VR, Pavitt S, Wu J. Risk of incident cardiovascular disease in people with periodontal disease: a systematic review and meta‐analysis. ClinExpDentRes. 2021 Feb;7(1):109-122. DOI:

Lazureanu PC, Popescu FG, Stef L, Focsa M, Vaida MA, Mihaila R. The influence of periodontal disease on oral health quality of life in patients with cardiovascular disease: a cross-sectional observational single-center study. Medicina. 2022 Apr 24;58(5):584. DOI:

Tiensripojamarn N, Lertpimonchai A, Tavedhikul K, et al. Periodontitis is associated with cardiovascular diseases: a 13‐year study. J Clin Periodontol. 2021 Mar;48(3):348-356. DOI:

Petrenya N, Hopstock LA, Holde GE, Oscarson N, Jönsson B. Relationship between periodontitis and risk of cardiovascular disease: insights from the Tromsø Study. J Periodontol. 2022 Sep;93(9):1353-1365. DOI:

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How to Cite

Shetty B, Fazal I, Khan SF, Nambiar M, Irfana D K, Prasad R, Raj A. Association between cardiovascular diseases and periodontal disease: more than what meets the eye. dti [Internet]. 2023 Feb. 2 [cited 2023 Apr. 1];17(1):31-8. Available from:
Received 2022-10-25
Accepted 2022-11-10
Published 2023-02-02