The role of microRNAs in COVID-19 with a focus on miR-200c


  • Hadi Sodagar Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia - Iran
  • Shahriar Alipour Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia and Student Research Committee, Urmia University of Medical Sciences, Urmia - Iran
  • Sepideh Hasani Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia - Iran
  • Shiva Gholizadeh-Ghaleh Aziz Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia - Iran
  • Mohammad Hasan Khadem Ansari Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia - Iran
  • Rahim Asghari Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia and Hematology, Immune Cell Therapy and Stem Cells Transplantation Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia - Iran



Covid-19, Epigenetic, Lung diseases, miR-200c, miRNAs


Objective: Epigenetics is a quickly spreading scientific field, and the study of epigenetic regulation in various diseases such as infectious diseases is emerging. The microribonucleic acids (miRNAs) as one of the types of epigenetic processes bind to their target messenger RNAs (mRNAs) and regulate their stability and/or translation. This study aims to evaluate non-coding RNAs (ncRNAs) with a focus on miR-200c in COVID-19. In this review, we first define the epigenetics and miRNAs, and then the role of miRNAs in diseases focusing on lung diseases is explained. Finally, in this study, we will investigate the role and position of miRNAs with a focus on miR-200c in viral and severe acute respiratory syndrome–related coronavirus (SARS-CoV2) infections.

Methods: Systematic search of MEDLINE, PubMed, Web of Science, Embase, and Cochrane Library was conducted for all relative papers from 2000 to 2021 with the limitations of the English language. Finally, we selected 128 articles which fit the best to our objective of study, among which 5 articles focused on the impact of miR-200c.

Results: Due to the therapeutic results of various drugs in different races and populations, epigenetic processes, especially miRNAs, are important. The overall results showed that different types of miRNAs can be effective on the process of various lung diseases through different target pathways and genes. It is likely that amplified levels of miR-200c may lead to decreased angiotensin-converting enzyme-2 (ACE2) expression, which in turn may increase the potential of infection, inflammation, and the complications of coronavirus disease.

Conclusion: miR-200c and its correlation with ACE2 can be used as early prognostic and diagnostic markers.


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How to Cite

Sodagar H, Alipour S, Hasani S, Gholizadeh-Ghaleh Aziz S, Khadem Ansari MH, Asghari R. The role of microRNAs in COVID-19 with a focus on miR-200c. J Circ Biomark [Internet]. 2022 Mar. 21 [cited 2023 Sep. 28];11(1):14-23. Available from:
Received 2021-11-05
Accepted 2022-02-22
Published 2022-03-21