Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease

Authors

  • Luisa Albanese Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Gemma Caliendo Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Giovanna D'Elia Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Luana Passariello Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Anna Maria Molinari Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples and Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Claudio Napoli Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania “Luigi Vanvitelli”, Naples and Clinical Department of Internal Medicine and Specialistic Units, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Maria Teresa Vietri Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples and Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples - Italy

DOI:

https://doi.org/10.33393/jcb.2022.2328

Keywords:

Bone density, CDK, FGF-23

Abstract

Our data confirm that intact fibroblast growth factor 23 (iFGF-23) concentration is increased in patients with chronic kidney disease (CKD) and that it increases with disease progression (stages I-V). Therefore, iFGF-23 could be considered an early biomarker in the course of chronic kidney disease-mineral bone disorder (CKD-MBD), which has several aspects that make it potentially useful in clinical practice. The availability of an automated method for iFGF-23 assay may represent an added value in the management of the patient with CKD-MBD already from the early stages of the disease, before the increase of the routinely used laboratory parameters, 1-84 parathyroid hormone (PTH) and 25-OH-vitamin D (25-OH-vitD), which occur in more advanced stages of the disease.

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Published

2022-01-08

How to Cite

Albanese, L., Caliendo, G., D’Elia, G., Passariello, L., Molinari, A. M., Napoli, C., & Vietri, M. T. (2022). Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease. Journal of Circulating Biomarkers, 11(1), 1–4. https://doi.org/10.33393/jcb.2022.2328

Issue

Vol. 11 No. 1 (2022): January-December 2022

Section

Short communication

License

Copyright (c) 2022 Luisa Albanese, Gemma Caliendo, Giovanna D'Elia, Luana Passariello, Anna Maria Molinari, Claudio Napoli, Maria Teresa Vietri

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors contributing to Journal of Circulating Biomarkers agree to publish their articles under the Creative Common Attribution Non Commercial 4.0 (CC-BY-NC 4.0) license, which allows third parties to re-use the work without permission as long as the work is properly referenced and the use is non-commercial.

Received 2021-08-04
Accepted 2021-12-06
Published 2022-01-08

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