Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease
DOI:
https://doi.org/10.33393/jcb.2022.2328Keywords:
Bone density, CDK, FGF-23Abstract
Our data confirm that intact fibroblast growth factor 23 (iFGF-23) concentration is increased in patients with chronic kidney disease (CKD) and that it increases with disease progression (stages I-V). Therefore, iFGF-23 could be considered an early biomarker in the course of chronic kidney disease-mineral bone disorder (CKD-MBD), which has several aspects that make it potentially useful in clinical practice. The availability of an automated method for iFGF-23 assay may represent an added value in the management of the patient with CKD-MBD already from the early stages of the disease, before the increase of the routinely used laboratory parameters, 1-84 parathyroid hormone (PTH) and 25-OH-vitamin D (25-OH-vitD), which occur in more advanced stages of the disease.
References
- Moe S, Drüeke T, Cunningham J, et al; Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69(11):1945-1953. https://doi.org/10.1038/sj.ki.5000414 PMID:16641930
- Hu MC, Shiizaki K, Kuro-o M, Moe OW. Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol. 2013;75(1):503-533. https://doi.org/10.1146/annurev-physiol-030212-183727 PMID:23398153
- Ho BB, Bergwitz C. FGF23 signalling and physiology. J Mol Endocrinol. 2021;66(2):R23-R32. https://doi.org/10.1530/JME-20-0178 PMID:33338030
- Shimada T, Urakawa I, Isakova T, et al. Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J Clin Endocrinol Metab. 2010;95(2):578-585. https://doi.org/10.1210/jc.2009-1603 PMID:19965919
- Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators—a critical appraisal. Cell Metab. 2012;16(6):693-705. https://doi.org/10.1016/j.cmet.2012.11.001 PMID:23217254
- Wolf M. Update on fibroblast growth factor 23 in chronic kidney disease. Kidney Int. 2012;82(7):737-747. https://doi.org/10.1038/ki.2012.176 PMID:22622492
- Bergwitz C, Jüppner H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med. 2010;61(1):91-104. https://doi.org/10.1146/annurev.med.051308.111339PMID:20059333
- Isakova T, Wahl P, Vargas GS, et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int. 2011;79(12):1370-1378. https://doi.org/10.1038/ki.2011.47 PMID:21389978
- Isakova T, Xie H, Yang W, et al; Chronic Renal Insufficiency Cohort (CRIC) Study Group. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA. 2011;305(23):2432-2439. https://doi.org/10.1001/jama.2011.826PMID:21673295
- Takashi Y, Fukumoto S. FGF23 beyond Phosphotropic Hormone. Trends Endocrinol Metab. 2018;29(11):755-767. https://doi.org/10.1016/j.tem.2018.08.006 PMID:30217676
- Shimizu Y, Fukumoto S, Fujita T. Evaluation of a new automated chemiluminescence immunoassay for FGF23. J Bone Miner Metab. 2012;30(2):217-221. https://doi.org/10.1007/s00774-011-0306-4 PMID:21898178
- Souberbielle JC, Prié D, Piketty ML, et al. Evaluation of a New Fully Automated Assay for Plasma Intact FGF23. Calcif Tissue Int. 2017;101(5):510-518. https://doi.org/10.1007/s00223-017-0307-y PMID:28761972
- Napoli C, Casamassimi A, Crudele V, Infante T, Abbondanza C. Kidney and heart interactions during cardiorenal syndrome: a molecular and clinical pathogenic framework. Future Cardiol. 2011;7(4):485-497. https://doi.org/10.2217/fca.11.24 PMID:21797745
- Vasco M, Benincasa G, Fiorito C, et al. Clinical epigenetics and acute/chronic rejection in solid organ transplantation: an update. Transplant Rev (Orlando). 2021;35(2):100609. https://doi.org/10.1016/j.trre.2021.100609 PMID:33706201
- Economidou D, Dovas S, Papagianni A, Pateinakis P, Memmos D. FGF-23 Levels before and after Renal transplantation. J Transplant. 2009;2009:379082. https://doi.org/10.1155/2009/379082PMID:20107581