Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease

Authors

  • Luisa Albanese Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Gemma Caliendo Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Giovanna D'Elia Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Luana Passariello Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Anna Maria Molinari Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples and Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Claudio Napoli Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania “Luigi Vanvitelli”, Naples and Clinical Department of Internal Medicine and Specialistic Units, AOU, University of Campania “Luigi Vanvitelli”, Naples - Italy
  • Maria Teresa Vietri Unity of Clinical and Molecular Pathology, AOU, University of Campania “Luigi Vanvitelli”, Naples and Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples - Italy

DOI:

https://doi.org/10.33393/jcb.2022.2328

Keywords:

Bone density, CDK, FGF-23

Abstract

Our data confirm that intact fibroblast growth factor 23 (iFGF-23) concentration is increased in patients with chronic kidney disease (CKD) and that it increases with disease progression (stages I-V). Therefore, iFGF-23 could be considered an early biomarker in the course of chronic kidney disease-mineral bone disorder (CKD-MBD), which has several aspects that make it potentially useful in clinical practice. The availability of an automated method for iFGF-23 assay may represent an added value in the management of the patient with CKD-MBD already from the early stages of the disease, before the increase of the routinely used laboratory parameters, 1-84 parathyroid hormone (PTH) and 25-OH-vitamin D (25-OH-vitD), which occur in more advanced stages of the disease.

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Published

2022-01-08

How to Cite

1.
Albanese L, Caliendo G, D’Elia G, Passariello L, Molinari AM, Napoli C, Vietri MT. Diagnostic utility of FGF-23 in mineral bone disorder during chronic kidney disease. J Circ Biomark [Internet]. 2022 Jan. 8 [cited 2022 Jun. 28];11(1):1-4. Available from: https://journals.aboutscience.eu/index.php/jcb/article/view/2328

Issue

Section

Short communication