Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review

  • Sittichai Khamsai Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Kittisak Sawanyawisuth Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Vichai Senthong Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Panita Limpawattana Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Jarin Chindaprasirt Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Pewpan M Intapan Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Wanchai Maleewong Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Somsak Tiamkao Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Verajit Chotmongkol Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - Thailand
  • Chetta Ngamjarus Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen - Thailand
Keywords: Angiostrongylus cantonensis, Headache, Prednisolone

Abstract

Background: Eosinophilic meningitis (EOM) is an emerging parasitic disease that can be found worldwide, of which acute severe headache is a presenting symptom. Although such headaches may persist for up to 2 months, studies have found corticosteroid to be effective in reducing this symptom. As the most recent systematic review was published in 2015, the aim of this study was to provide a more up-to-date examination of the role of corticosteroids in EOM.

Methods: We included randomized controlled trials of corticosteroid treatment for EOM regardless of comparators. Research articles published in five databases were searched and evaluated. The primary outcome was headache, which was compared among various treatment regimens.

Results: We found a total of 257 articles after duplication removal. Of those, two met the study criteria. According to these studies, oral prednisolone alone or in a combination of albendazole resulted in fewer patients with headache after a 2-week course of treatment compared with placebo (maximum of 9.1% vs. 45.5%). The duration of headache was also shorter in the prednisolone arm vs. placebo (maximum of 5 vs. 13 days). There were no serious side effects reported.

Conclusion: A 2-week course of treatment with oral corticosteroid with or without albendazole reduced headaches in patients with EOM.

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Published
2021-03-08
How to Cite
1.
Khamsai S, Sawanyawisuth K, Senthong V, Limpawattana P, Chindaprasirt J, Intapan P, Maleewong W, Tiamkao S, Chotmongkol V, Ngamjarus C. Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review. DTI [Internet]. 8Mar.2021 [cited 11Apr.2021];15(1):1-. Available from: https://journals.aboutscience.eu/index.php/dti/article/view/2197
Section
Review