Licorice as a herbal extract in periodontal therapy


  • Safiya Fatima Khan Department of Periodontology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore - India
  • Bhavya Shetty Department of Periodontology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore - India
  • Ibrahim Fazal Department of Periodontology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bangalore - India
  • Asim Mustafa Khan Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam - Saudi Arabia
  • Faheem Muzaffar Mir Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam - Saudi Arabia
  • Muhamood Moothedath Department of Oral and Dental Health, College of Applied Health Sciences in Arrass, Qassim University, Buraidah - Saudi Arabia
  • Reshma VJ Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam - Saudi Arabia
  • Muhaseena Muhamood Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam - Saudi Arabia



Gingivitis, Glycyrrhiza glabra, Herbal therapy, Periodontitis


Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of Glycyrrhiza uralensis and G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.


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How to Cite

Khan, S. F., Shetty, B., Fazal, I., Mustafa Khan, A., Muzaffar Mir, F., Moothedath, M., VJ, R., & Muhamood, M. (2023). Licorice as a herbal extract in periodontal therapy. Drug Target Insights, 17(1), 70–77.
Received 2023-03-20
Accepted 2023-05-18
Published 2023-06-05