Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome

Asmaa Elsehmawy; Rasha Mahmoud Gouda; Fatma Elzhraa Ahmed Diab; Ola Ismail Saleh; Heba Mohamed Galal; Mona Gamal El Din Al Anany; Salwa Samir Abd Elgwad; Marwa Mohsen Hassan; Mohamed Ahmed Mostafa Kamal Ahmed; Ahmed Yousri Elamir

doi:10.33393/jcb.2024.2689

Authors

Asmaa Elsehmawy Pediatric Department, Al-Azhar University, Cairo - Egypt
Rasha Mahmoud Gouda Pediatric Department, Al-Azhar University, Cairo - Egypt
Fatma Elzhraa Ahmed Diab Clinical Pathology Department, Al-Azhar University, Cairo - Egypt
Ola Ismail Saleh Radiology Department, Al-Azhar University, Cairo - Egypt
Heba Mohamed Galal Radiology Department, Al-Azhar University, Cairo - Egypt
Mona Gamal El Din Al Anany Physiology Department, Al-Azhar University, Cairo - Egypt and Armed Forces College of Medicine, Cairo - Egypt
Salwa Samir Abd Elgwad Pediatric Department, Al-Azhar University, Cairo - Egypt
Marwa Mohsen Hassan Community Medicine Department, Al-Azhar University, Cairo - Egypt
Mohamed Ahmed Mostafa Kamal Ahmed Clinical Pathology Department, Al-Azhar University, Cairo - Egypt
Ahmed Yousri Elamir Radiology Department, Cairo University, Cairo - Egypt

DOI:

https://doi.org/10.33393/jcb.2024.2689

Keywords:

Annexin-V, Carotid intima-media thickness, Idiopathic nephrotic syndrome, Interleukin-13

Abstract

Background and aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).

Materials and methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.

Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.

Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.

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