Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome


  • Asmaa Elsehmawy Pediatric Department, Al-Azhar University, Cairo - Egypt
  • Rasha Mahmoud Gouda Pediatric Department, Al-Azhar University, Cairo - Egypt
  • Fatma Elzhraa Ahmed Diab Clinical Pathology Department, Al-Azhar University, Cairo - Egypt
  • Ola Ismail Saleh Radiology Department, Al-Azhar University, Cairo - Egypt
  • Heba Mohamed Galal Radiology Department, Al-Azhar University, Cairo - Egypt
  • Mona Gamal El Din Al Anany Physiology Department, Al-Azhar University, Cairo - Egypt and Armed Forces College of Medicine, Cairo - Egypt
  • Salwa Samir Abd Elgwad Pediatric Department, Al-Azhar University, Cairo - Egypt
  • Marwa Mohsen Hassan Community Medicine Department, Al-Azhar University, Cairo - Egypt
  • Mohamed Ahmed Mostafa Kamal Ahmed Clinical Pathology Department, Al-Azhar University, Cairo - Egypt
  • Ahmed Yousri Elamir Radiology Department, Cairo University, Cairo - Egypt



Annexin-V, Carotid intima-media thickness, Idiopathic nephrotic syndrome, Interleukin-13


Background and aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).

Materials and methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.

Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.

Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.


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How to Cite

Elsehmawy, A., Gouda, R. M., Diab, F. E. A., Saleh, O. I., Galal, H. M., Al Anany, M. G. E. D., Abd Elgwad, S. S., Hassan, M. M., Ahmed, M. A. M. K., & Elamir, A. Y. (2024). Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome. Journal of Circulating Biomarkers, 13(1), 7–13.



Original research article
Received 2023-10-22
Accepted 2024-05-16
Published 2024-06-18