Budget impact analysis of rituximab biosimilar in Italy from the hospital and payer perspectives

Authors

  • Carla Rognoni Centre for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy
  • Arianna Bertolani Centre for Research on Health and Social Care Management (CERGAS), SDA Bocconi University, Milan, Italy
  • Claudio Jommi Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy

DOI:

https://doi.org/10.33393/grhta.2018.440

Keywords:

Rituximab, biosimilar, budget impact analysis, economic evaluation

Abstract

Introduction: This article aims at investigating the 5-year budget impact of rituximab biosimilars in Italy. Methods: A budget impact analysis model was developed in accordance with the International Society For Pharmacoeconomics and Outcomes Research recommendations. Drug acquisition and drug administration costs were considered since the risk/benefit profile of biosimilars and the originator was assumed to be overlapping. The perspectives of hospitals and payers were used. Input data were retrieved from the literature and validated/integrated by an expert panel of seven clinicians from various Italian regions. A dynamic incidence-based approach was used. Results: From the hospital perspective, adopting a rituximab biosimilar would produce savings of €79.2 and €153.6 million over 3 and 5 years, respectively. The results are very similar if the payer perspective is considered, with a cumulated savings of about €153.4 million in 5 years. Lymphoma and chronic lymphocytic leukaemia would account for the most significant savings. Discussion: Despite its limitations, this study provides the first Italian evaluation of the financial impact of rituximab biosimilars and also incorporates the effects of biosimilars on the pricing strategies of the originator (dynamic impact). This dynamic effect is more relevant than the impact of the treatment shift from the originator to biosimilars. Our hope is that these savings will be used to cover new cost-effective drugs and not just for cost-cutting policies.

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Published

2018-06-29

How to Cite

1.
Rognoni C, Bertolani A, Jommi C. Budget impact analysis of rituximab biosimilar in Italy from the hospital and payer perspectives. Grhta [Internet]. 2018 Jun. 29 [cited 2022 May 24];5(1). Available from: https://journals.aboutscience.eu/index.php/grhta/article/view/440

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Section

Original Research Article

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