Cost-effectiveness analysis of paliperidone palmitate versus long-acting risperidone as maintenance treatment in schizophrenia patients in Italy

Analisi di costo efficacia di paliperidone palmitato rispetto a risperidone a rilascio prolungato nel trattamento di mantenimento dei pazienti affetti da schizofrenia in Italia

Authors

  • Roberto Ravasio Health Publishing & Services Srl, Milano - Italy
  • Giuseppe Nicolò Dipartimento Salute Mentale ASL Roma G, Roma - Italy
  • Marco Vaggi Dipartimento Salute Mentale e Dipendenze ASL 3 Genovese, Genova - Italy

DOI:

https://doi.org/10.33393/grhta.2015.321

Keywords:

Paliperidone palmitate, cost-effectiveness, schizophrenia, QALY

Abstract

Objective To evaluate the cost-effectiveness of paliperidone palmitate (paliperidone long-acting injectable; PP) compared with long-acting injectable risperidone (RRP) in multi-episode patients (two or more relapses) with schizophrenia in Italy. Methods A pre-existing Markov model was utilized to simulate the history of a cohort of multi-episode patients transitioning through different health states on a monthly basis over a 12 or 24 month horizon from the perspective of the Italian National Health Service. Therapeutic strategies consisted of treatment with long-acting injectable risperidone (mean dose 37.5 mg every 2 weeks) or paliperidone palmitate (mean dose 75 mg equivalent [eq.] every month). Probability of relapse, level of adherence, side effects (extrapyramidal symptoms, tardive dyskinesia, weight gain and diabetes) and treatment discontinuation (switch) were derived from long-term observational data when feasible. The cost-effectiveness analysis considered quality adjusted life-years (QALYs) and direct medical costs. QALYs and costs (expressed in 2014 euro) were discounted at 3% annually. A one-way sensitivity analysis and a probabilistic sensitivity analysis were conducted. Results Paliperidone palmitate is the dominant long-acting injectable therapeutic option: a more effective (additional QALYs, less relapses) and less costly treatment option compared with long-acting injectable risperidone over a 12 or 24 month horizon. Results were robust when tested in sensitivity and probabilistic analyses. Conclusions Paliperidone palmitate was cost-saving from the Italian National Health Service perspective compared with long-acting injectable risperidone in the long-term treatment of multi-episode (two or more relapses) schizophrenia patients.

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Published

2014-12-18

How to Cite

Ravasio, R., Nicolò, G., & Vaggi, M. (2014). Cost-effectiveness analysis of paliperidone palmitate versus long-acting risperidone as maintenance treatment in schizophrenia patients in Italy: Analisi di costo efficacia di paliperidone palmitato rispetto a risperidone a rilascio prolungato nel trattamento di mantenimento dei pazienti affetti da schizofrenia in Italia. Global and Regional Health Technology Assessment, 2(1), 17–32. https://doi.org/10.33393/grhta.2015.321

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Original Research Articles

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