Molecular targets and therapeutic potential of baicalein: a review


  • Kavita Munjal Department of Pharmacognosy, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh - India
  • Yash Goel Department of Pharmacy, M.M. College of Pharmacy, M.M. (Deemed to be University), Mullana, Ambala, Haryana - India
  • Vinod Kumar Gauttam Department of Pharmacognosy, Shiva Institute of Pharmacy, Bilaspur, Himachal Pradesh - India
  • Hitesh Chopra Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu - India
  • Madhav Singla Department of Pharmacy, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab - India
  • Smriti Department of Pharmacy, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab - India
  • Saurabh Gupta Department of Pharmacology, Chameli Devi Institute of Pharmacy, Indore, Madhya Pradesh - India
  • Rohit Sharma Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh - India



Alzheimer’s, Baicalein, Cancer, Epilepsy, Heart failure, Hypertension, Parkinson, Stroke


Aim: Researchers using herbs and natural products to find new drugs often prefer flavonoids because of their potential as antioxidants and anti-inflammatories. The planned review addressed baicalein research findings in detail. This manuscript provides a complete review of baicalein’s potential pharmacological effects along with several molecular targets for better understanding of its therapeutic activities.

Materials and methods: We targeted the review on in vitro and in vivo studies reported on baicalein. For this, the literature is gathered from the database available on search engines like PubMed, ScienceDirect, Scopus, and Google Scholar up to 21 December 2023. The keywords “Scutellaria baicalensis”, “Oroxylum indicum”, “Neuroprotective”, “Cardioprotective”, “Toxicity studies”, and “Baicalein” were used to fetch the content.

Results: Baicalein’s molecular receptor binding approach has shown anticancer, antidiabetic, antimicrobial, antiaging, neuroprotective, cardioprotective, respiratory protective, gastroprotective, hepatic protective, and renal protective effects. The synergistic effects of this drug with other selective herbs are also contributed towards significant therapeutic potential.

Conclusion: This systematic review article from a contemporary and scientific perspective offers fresh insight into S. baicalensisO. indicum, and its bioactive component baicalein as a potential complementary medicine. Baicalein may be transformed into more efficacious and acceptable evidence-based medicine. However, we recommend more clinical and mechanistic approaches to confirm safety and efficacy of baicalein.


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How to Cite

Munjal, K., Goel, Y., Gauttam, V. K., Chopra, H., Singla, M., Smriti, Gupta, S., & Sharma, R. (2024). Molecular targets and therapeutic potential of baicalein: a review. Drug Target Insights, 18(1), 30–46.
Received 2023-11-06
Accepted 2024-01-11
Published 2024-06-06