The role of patient preferences in adherence to treatment in chronic disease: a narrative review

Authors

  • Serena Losi Eli Lilly Italy S.p.A., Sesto Fiorentino - Italy
  • Cesare Celeste Federico Berra IRCCS MultiMedica, Sesto San Giovanni, Milano - Italy
  • Riccardo Fornengo S.S.D. di Diabetologia ASL TO4, Torino - Italy
  • Dario Pitocco Diabetes Care Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma - Italy
  • Giovanni Biricolti Eli Lilly Italy S.p.A., Roma - Italy
  • Marco Orsini Federici Eli Lilly Italy S.p.A., Sesto Fiorentino - Italy

DOI:

https://doi.org/10.33393/dti.2021.2342

Keywords:

Adherence, Chronic disease, Preferences, Therapy

Abstract

Adherence to prescribed medication is important to the management of all diseases, especially those of chronic nature. Drug effectiveness is substantially compromised by therapy nonadherence. We reviewed the available evidences on the impact of patient preferences for therapy on adherence to a prescribed treatment in chronic diseases requiring long-term treatment. A search on PubMed retrieved 699 publications, leading to a selection of 12 publications: 6 on osteoporosis, 2 on moderate-to-severe asthma, 1 on type 1 diabetes, 1 on type 2 diabetes, 1 on kidney transplantation, and 1 on atrial fibrillation. Overall, 8 studies found a positive association between patient preference and adherence to therapy, while the others found no association. In general, overall adherence was considered to be high in the published studies. The reasons for a positive association included reduced dosing frequency, route of administration, lower costs, and favorable safety profile, which is related to the diverse nature of the pathology and its type and duration of treatment. A literature review suggests that achieving good adherence and persistence to therapy requires evaluation of patient preferences. In a period of increasingly limited resources, more effort is warranted to promote better adherence to therapy, especially when patients must self-manage their disease in the long term. Our results further highlight that insufficient attention has been given to the relationship between patient preference and adherence and point out the complex nature of adherence and the need for adequate patient education. More efforts are also needed to better understand the entity of cost savings for payers for specific treatments and the link with patient preference.

References

Davies MJ, D’Alessio DA, Fradkin J, et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018;41(12):2669-2701. https://doi.org/10.2337/dci18-0033 PMID:30291106 DOI: https://doi.org/10.2337/dci18-0033

World Health Organization. Adherence to long-term therapies: evidence for action. https://www.who.int/chp/knowledge/publications/adherence_full_report.pdf?ua=1. Accessed 7 July 7, 2020.

Haynes RB, McDonald H, Garg AX, Montague P. Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst Rev. 2002;(2):CD000011. PMID:12076376 DOI: https://doi.org/10.1002/14651858.CD000011

Egede LE, Gebregziabher M, Echols C, Lynch CP. Longitudinal effects of medication nonadherence on glycemic control. Ann Pharmacother. 2014;48(5):562-570. https://doi.org/10.1177/1060028014526362 PMID:24586059 DOI: https://doi.org/10.1177/1060028014526362

Martin LR, Williams SL, Haskard KB, Dimatteo MR. The challenge of patient adherence. Ther Clin Risk Manag. 2005;1(3):189-199. PMID:18360559

Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004;27(5):1218-1224. https://doi.org/10.2337/diacare.27.5.1218 PMID:15111553 DOI: https://doi.org/10.2337/diacare.27.5.1218

Ferdinand KC, Yadav K, Nasser SA, et al. Disparities in hypertension and cardiovascular disease in blacks: the critical role of medication adherence. J Clin Hypertens (Greenwich). 2017;19(10):1015-1024. https://doi.org/10.1111/jch.13089 PMID:28856834 DOI: https://doi.org/10.1111/jch.13089

Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836-1841. https://doi.org/10.1001/archinte.166.17.1836 PMID:17000939 DOI: https://doi.org/10.1001/archinte.166.17.1836

Boye KS, Curtis SE, Lage MJ, Garcia-Perez LE. Associations between adherence and outcomes among older, type 2 diabetes patients: evidence from a Medicare Supplemental database. Patient Prefer Adherence. 2016;10:1573-1581. https://doi.org/10.2147/PPA.S107543 PMID:27574406 DOI: https://doi.org/10.2147/PPA.S107543

Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43(6):521-530. https://doi.org/10.1097/01.mlr.0000163641.86870.af PMID:15908846 DOI: https://doi.org/10.1097/01.mlr.0000163641.86870.af

Tiktin M, Celik S, Berard L. Understanding adherence to medications in type 2 diabetes care and clinical trials to overcome barriers: a narrative review. Curr Med Res Opin. 2016;32(2):277-287. https://doi.org/10.1185/03007995.2015.1119677 PMID:26565758 DOI: https://doi.org/10.1185/03007995.2015.1119677

Gelhorn HL, Sexton CC, Classi PM. Patient preferences for treatment of major depressive disorder and the impact on health outcomes: a systematic review. Prim Care Companion CNS Disord. 2011;13(5):PCC.11r01161. https://doi.org/10.4088/PCC.11r01161 PMID:22295273 DOI: https://doi.org/10.4088/PCC.11r01161

Brazier JE, Dixon S, Ratcliffe J. The role of patient preferences in cost-effectiveness analysis: a conflict of values? PharmacoEconomics. 2009;27(9):705-712. https://doi.org/10.2165/11314840-000000000-00000 PMID:19757864 DOI: https://doi.org/10.2165/11314840-000000000-00000

Gentile S, Strollo F. Aderenza e semplicità: quale ruolo nella terapia con GLP1-RA. Collana Editoriale Associazione Medici Diabetologi. https://www.pacinimedicina.it/prodotto/aderenza-e-semplicita-quale-ruolo-nella-terapia-con-glp1-ra/. Accessed November 10, 2020.

Green BN, Johnson CD, Adams A. Writing narrative literature reviews for peer-reviewed journals: secrets of the trade. J Chiropr Med. 2006;5(3):101-117. https://doi.org/10.1016/S0899-3467(07)60142-6 PMID:19674681 DOI: https://doi.org/10.1016/S0899-3467(07)60142-6

Ledade SD, Jain SN, Darji AA, Gupta VH. Narrative writing: effective ways and best practices. Perspect Clin Res. 2017;8(2):58-62. https://doi.org/10.4103/2229-3485.203044PMID:28447014 DOI: https://doi.org/10.4103/2229-3485.203044

Pautasso M. Ten simple rules for writing a literature review. PLOS Comput Biol. 2013;9(7):e1003149. https://doi.org/10.1371/journal.pcbi.1003149 PMID:23874189 DOI: https://doi.org/10.1371/journal.pcbi.1003149

van Hoorn R, Kievit W, Booth A, et al. The development of PubMed search strategies for patient preferences for treatment outcomes. BMC Med Res Methodol. 2016;16(1):88. https://doi.org/10.1186/s12874-016-0192-5 PMID:27473226 DOI: https://doi.org/10.1186/s12874-016-0192-5

Siddaway AP, Wood AM, Hedges LV. How to do a systematic review: a best practice guide for conducting and reporting narrative reviews, meta-analyses, and meta-syntheses. Annu Rev Psychol. 2019;70(1):747-770. https://doi.org/10.1146/annurev-psych-010418-102803PMID:30089228 DOI: https://doi.org/10.1146/annurev-psych-010418-102803

Centers for Disease Control and Prevention. About Chronic Diseases. https://www.cdc.gov/chronicdisease/about/index.htm. Accessed November 10, 2020.

Kendler DL, Macarios D, Lillestol MJ, et al. Influence of patient perceptions and preferences for osteoporosis medication on adherence behavior in the Denosumab Adherence Preference Satisfaction study. Menopause. 2014;21(1):25-32. https://doi.org/10.1097/GME.0b013e31828f5e5d PMID:23676636 DOI: https://doi.org/10.1097/GME.0b013e31828f5e5d

Kendler DL, McClung MR, Freemantle N, et al; DAPS Investigators. Adherence, preference, and satisfaction of postmenopausal women taking denosumab or alendronate. Osteoporos Int. 2011;22(6):1725-1735. https://doi.org/10.1007/s00198-010-1378-z PMID:20827547 DOI: https://doi.org/10.1007/s00198-010-1378-z

Freemantle N, Satram-Hoang S, Tang ET, et al; DAPS Investigators. Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women. Osteoporos Int. 2012;23(1):317-326. https://doi.org/10.1007/s00198-011-1780-1 PMID:21927922 DOI: https://doi.org/10.1007/s00198-011-1780-1

Jarab AS, Mukattash TL, Hilan H. Medication non-adherence in patients with osteoporosis: implications for clinical pharmacists and osteoporosis care providers. Curr Clin Pharmacol. 2020;15(3):243-250. https://doi.org/10.2174/1574884715666200116104754 PMID:31951176 DOI: https://doi.org/10.2174/1574884715666200116104754

Eliasaf A, Amitai A, Maram Edry M, Yosselson Superstine S, Rotman Pikielny P. Compliance, persistence, and preferences regarding osteoporosis treatment during active therapy or drug holiday. J Clin Pharmacol. 2016;56(11):1416-1422. https://doi.org/10.1002/jcph.738 PMID:26999526 DOI: https://doi.org/10.1002/jcph.738

Sakai A, Ikeda S, Okimoto N, et al. Clinical efficacy and treatment persistence of monthly minodronate for osteoporotic patients unsatisfied with, and shifted from, daily or weekly bisphosphonates: the BP-MUSASHI study. Osteoporos Int. 2014;25(9):2245-2253. https://doi.org/10.1007/s00198-014-2756-8 PMID:24899103 DOI: https://doi.org/10.1007/s00198-014-2756-8

Oral A, Lorenc R; FLINT-ACT Study Investigators. Compliance, persistence, and preference outcomes of postmenopausal osteoporotic women receiving a flexible or fixed regimen of daily risedronate: a multicenter, prospective, parallel group study. Acta Orthop Traumatol Turc. 2015;49(1):67-74. https://doi.org/10.3944/AOTT.2015.14.0082 PMID:25803256 DOI: https://doi.org/10.3944/AOTT.2015.14.0082

Thomasius F, Keung Nip T, Ivan P. Phase IV randomized preference study in patients eligible for calcium and vitamin D supplementation. Curr Med Res Opin. 2016;32(10):1623-1631. https://doi.org/10.1080/03007995.2016.1202817 PMID:27322906 DOI: https://doi.org/10.1080/03007995.2016.1202817

Plaza V, Giner J, Calle M, et al. Impact of patient satisfaction with his or her inhaler on adherence and asthma control. Allergy Asthma Proc. 2018;39(6):437-444. https://doi.org/10.2500/aap.2018.39.4183 PMID:30336791 DOI: https://doi.org/10.2500/aap.2018.39.4183

Valero A, Ribó P, Maíz L, et al. Asthma patient satisfaction with different dry powder inhalers. Expert Rev Respir Med. 2019;13(2):133-138. https://doi.org/10.1080/17476348.2019.1567339PMID:30625015 DOI: https://doi.org/10.1080/17476348.2019.1567339

Al Hayek AA, Al Dawish M. Evaluating the user preference and level of insulin self-administration adherence in young patients with type 1 diabetes: experience with two insulin pen needle lengths. Cureus. 2020;12(6):e8673. https://doi.org/10.7759/cureus.8673PMID:32699673 DOI: https://doi.org/10.7759/cureus.8673

Ishii H, Hayashino Y, Akai Y, Yabuta M, Tsujii S. Dipeptidyl peptidase-4 inhibitors as preferable oral hypoglycemic agents in terms of treatment satisfaction: results from a multicenter, 12-week, open label, randomized controlled study in Japan (PREFERENCE 4 study). J Diabetes Investig. 2018;9(1):137-145. https://doi.org/10.1111/jdi.12659 PMID:28296349 DOI: https://doi.org/10.1111/jdi.12659

Wu S, Xie S, Xu Y, et al. Persistence and outcomes of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with non-valvular atrial fibrillation. J Clin Nurs. 2019;28(9-10):1839-1846. https://doi.org/10.1111/jocn.14797 PMID:30667111 DOI: https://doi.org/10.1111/jocn.14797

Hugo C, Weihprecht H, Banas B, et al. Renal function and patient-reported outcomes in stable kidney transplant patients following conversion from twice-daily immediate-release tacrolimus to once-daily prolonged-release tacrolimus: a 12-month observational study in routine clinical practice in Germany (ADAGIO). Transplant Proc. 2021;53(5):1484-1493. https://doi.org/10.1016/j.transproceed.2021.01.034 PMID:33610306 DOI: https://doi.org/10.1016/j.transproceed.2021.01.034

Boye K, Ross M, Mody R, Konig M, Gelhorn H. Patients’ preferences for once-daily oral versus once-weekly injectable diabetes medications: the REVISE study. Diabetes Obes Metab. 2021;23(2):508-519. https:doi.org/10.1111/dom.14244 PMID:33140575 DOI: https://doi.org/10.1111/dom.14244

Weycker D, Macarios D, Edelsberg J, Oster G. Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int. 2006;17(11):1645-1652. https://doi.org/10.1007/s00198-006-0179-x PMID:16862397 DOI: https://doi.org/10.1007/s00198-006-0179-x

Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160(21):3278-3285. https://doi.org/10.1001/archinte.160.21.3278 PMID:11088090 DOI: https://doi.org/10.1001/archinte.160.21.3278

Bruno G, Picariello R, Petrelli A, et al. Direct costs in diabetic and non diabetic people: the population-based Turin study, Italy. Nutr Metab Cardiovasc Dis. 2012;22(8):684-690. https://doi.org/10.1016/j.numecd.2011.04.007 PMID:21907553 DOI: https://doi.org/10.1016/j.numecd.2011.04.007

Marchesini G, Pasqualetti P, Anichini R, et al. Patient preferences for treatment in type 2 diabetes: the Italian discrete-choice experiment analysis. Acta Diabetol. 2019;56(3):289-299. https://doi.org/10.1007/s00592-018-1236-6 PMID:30306406 DOI: https://doi.org/10.1007/s00592-018-1236-6

Published

2021-11-08

How to Cite

1.
Losi S, Berra CCF, Fornengo R, Pitocco D, Biricolti G, Orsini Federici M. The role of patient preferences in adherence to treatment in chronic disease: a narrative review. dti [Internet]. 2021 Nov. 8 [cited 2021 Dec. 7];15(1):13-20. Available from: https://journals.aboutscience.eu/index.php/dti/article/view/2342

Issue

Section

Review