Antibodies Against Gonadotropin-Releasing Hormone in Patients with Posterior Laryngitis

Hillevi Pendleton; Ragnar Alm; Gunilla Nordin Fredrikson; Bodil Ohlsson

doi:10.33393/dti.2013.1374

Authors

Hillevi Pendleton Department of Clinical Sciences, Division of Otorhinolaryngology, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.
Ragnar Alm Department of Clinical Sciences, Experimental Cardiovascular Research Unit, Skåne University Hospital, Malmö, Lund University.
Gunilla Nordin Fredrikson Faculty of Health and Society, Malmö University, Sweden.
Bodil Ohlsson Department of Clinical Sciences, Division of Gastroenterology, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.

DOI:

https://doi.org/10.33393/dti.2013.1374

Keywords:

gonadotropin-releasing hormone, posterior laryngitis, functional disorders, acid reflux

Abstract

Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Consecutive PL patients were included after examination. Serum was analyzed for the presence of antibodies using an enzyme-linked immunosorbent assay (ELISA) method and expressed as relative units (RU). Two age- and gender-matched healthy subjects per case served as controls. The prevalence of IgM GnRH antibodies in patients was 35% compared with 28% in controls (P = 0.06), with higher levels in patients (0.8 (0.3–2.2) RU) than in controls (0.2 (0.1–0.6) RU) (P = 0.007). The corresponding IgG antibody prevalences were 43% and 4%, respectively (P = 0.001), with no difference in levels (P = 0.70). There was no association between antibodies and clinical findings.