Hand hygiene for prevention and control of viral infections: the role of Amuchina Gel Xgerm [Accepted for publication]

Abstract

Introduction: Alcohol-based hand sanitizers are used in healthcare settings, but their efficacy against both enveloped and non-enveloped viruses requires further investigation.

Methods: In this study, viral suspensions composed by the test virus, an interfering substance, and the test product, were exposed to Amuchina Gel Xgerm (100 g of the product contains 74 g of ethanol 96%; Angelini Pharma S.p.A) at 80% dilution in water, according to the European Standard EN14476:2013+A2:2019 –quantitative suspension test for the evaluation of virucidal activity in the medical area– for chemical disinfectants and antiseptics, in the presence of bovine serum albumin 0.3 g/L. The residual viral titers were measured.

Results: Sixty second exposures to the product determined a ≥4 log₁₀ reduction of virus titer in all cases. For adenovirus type 5, human coxsakievirus, herpesvirus 1 and influenza virus A H1N1, a ≥4 log₁₀ reduction of virus titer was obtained already after 30 s. Amuchina Gel Xgerm demonstrated effectiveness against seven virus families, including both enveloped and non-enveloped viruses.

Conclusion: Amuchina Gel Xgerm is a preventive measure against infection spread in healthcare and community settings, contributing to improved healthcare management.