Fournier’s gangrene wounds successfully healed with High pbserum enzymes: a case report




Collagenase, Enzymes, Fournier’s gangrene, recombinant


Fournier’s gangrene is an aggressive form of infective necrotizing fasciitis in the perianal and genital area. In this article we discuss the case of a 75-year-old male patient diagnosed with Fournier’s gangrene with the entire perianal region affected. Surgical washings were performed and debridement with multiple flaps were required for reconstruction. Complications in the suture wounds, cavities, and a seroma were observed after 5 weeks, and they were treated with dressings. Treatment with High pbserum recombinant enzymes was initiated after 3 weeks, to accelerate the closure of the wounds. The granulation tissue was irrigated by drip irrigation once every 3 weeks, ensuring good tissue impregnation. We observed that the epithelialization of the affected areas was achieved after the first week, and in 1 month, most of the wounds healed properly without signs of infection. High pbserum is an enzyme cocktail, composed of higher collagenase concentration, lipase, and liase. This study shows how High pbserum improves and accelerates wound healing in a patient with Fournier’s gangrene. Further investigations are needed to conclude treatment recommendations.


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How to Cite

Paris, E., & López Berroa, J. (2024). Fournier’s gangrene wounds successfully healed with High pbserum enzymes: a case report. AboutOpen, 11(1), 18–20.



Case report


Received 2023-11-27
Accepted 2024-01-09
Published 2024-02-26