Management of bleeding in cardiac surgery patients


  • Marco Ranucci Unità di Anestesia e Terapia Intensiva Cardiovascolare, IRCCS Policlinico San Donato, San Donato Milanese (MI) - Italy



Algorithms, Cardiac surgery, Hemorrhage, Perioperative bleeding, Viscoelastic testing




Dyke C, Aronson S, Dietrich W, et al. Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg. 2014;147(5):1458-1463.e1. PMID:24332097

Ranucci M, Baryshnikova E. Sensitivity of Viscoelastic Tests to Platelet Function. J Clin Med. 2020;9(1):189. PMID:32284512

Raphael J, Mazer CD, Subramani S, et al. Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients. Anesth Analg. 2019;129(5):1209-1221. PMID:31613811

Ranucci M, Pistuddi V, Di Dedda U, Menicanti L, De Vincentiis C, Baryshnikova E. Platelet function after cardiac surgery and its association with severe postoperative bleeding: the PLATFORM study. Platelets. 2019;30(7):908-914. PMID:30365338

Ranucci M, Baryshnikova E, Crapelli GB, Rahe-Meyer N, Menicanti L, Frigiola A; Surgical Clinical Outcome REsearch (SCORE) Group. Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery. J Am Heart Assoc. 2015;4(6):e002066. PMID:26037084

Ranucci M, Baryshnikova E. Fibrinogen supplementation after cardiac surgery: insights from the Zero-Plasma trial (ZEPLAST). Br J Anaesth. 2016;116(5):618-623. PMID:26893405

Ranucci M, Pistuddi V, Baryshnikova E, Colella D, Bianchi P. Fibrinogen Levels After Cardiac Surgical Procedures: Association With Postoperative Bleeding, Trigger Values, and Target Values. Ann Thorac Surg. 2016;102(1):78-85.

Erdoes G, Koster A, Ortmann E, et al. A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and non-cardiac surgical patients. Anaesthesia. 2021;76(3):381-392. PMID:32681570



How to Cite

Ranucci M. Management of bleeding in cardiac surgery patients. abtpn [Internet]. 2022 Jul. 31 [cited 2022 Oct. 1];9(1):66-9. Available from:



Focus on the management of critical bleeding