Management of bleeding in cardiac surgery patients


  • Marco Ranucci Unità di Anestesia e Terapia Intensiva Cardiovascolare, IRCCS Policlinico San Donato, San Donato Milanese (MI) - Italy



Algorithms, Cardiac surgery, Hemorrhage, Perioperative bleeding, Viscoelastic testing




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Dyke C, Aronson S, Dietrich W, et al. Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg. 2014;147(5):1458-1463.e1. PMID:24332097 DOI:

Ranucci M, Baryshnikova E. Sensitivity of Viscoelastic Tests to Platelet Function. J Clin Med. 2020;9(1):189. PMID:32284512 DOI:

Raphael J, Mazer CD, Subramani S, et al. Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for Management of Perioperative Bleeding and Hemostasis in Cardiac Surgery Patients. Anesth Analg. 2019;129(5):1209-1221. PMID:31613811 DOI:

Ranucci M, Pistuddi V, Di Dedda U, Menicanti L, De Vincentiis C, Baryshnikova E. Platelet function after cardiac surgery and its association with severe postoperative bleeding: the PLATFORM study. Platelets. 2019;30(7):908-914. PMID:30365338 DOI:

Ranucci M, Baryshnikova E, Crapelli GB, Rahe-Meyer N, Menicanti L, Frigiola A; Surgical Clinical Outcome REsearch (SCORE) Group. Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery. J Am Heart Assoc. 2015;4(6):e002066. PMID:26037084 DOI:

Ranucci M, Baryshnikova E. Fibrinogen supplementation after cardiac surgery: insights from the Zero-Plasma trial (ZEPLAST). Br J Anaesth. 2016;116(5):618-623. PMID:26893405 DOI:

Ranucci M, Pistuddi V, Baryshnikova E, Colella D, Bianchi P. Fibrinogen Levels After Cardiac Surgical Procedures: Association With Postoperative Bleeding, Trigger Values, and Target Values. Ann Thorac Surg. 2016;102(1):78-85. DOI:

Erdoes G, Koster A, Ortmann E, et al. A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and non-cardiac surgical patients. Anaesthesia. 2021;76(3):381-392. PMID:32681570 DOI:



How to Cite

Ranucci, M. (2022). Management of bleeding in cardiac surgery patients. AboutOpen, 9(1), 66–69.



Focus on the management of critical bleeding


Received 2022-06-01
Accepted 2022-06-08
Published 2022-07-31