Inflammation management in ophthalmology: new evidences for cataract surgery and beyond

La gestione dell’infiammazione in oftalmologia: nuove evidenze per la chirurgia della cataratta e oltre

  • Matteo Piovella President (2010-2021) Italian Ophthalmological Society (SOI); Treasurer, Italian Federation of Medical Scientific Societies-FISM; General Secretary, Italian Union Association of Eye Doctors and Orthoptists-ASMOOI; President, “Together for Sight” Foundation; Medical Director Centro Microchirurgia Ambulatoriale-CMA, Monza (MB) - Italy https://orcid.org/0000-0002-1308-4958
  • Teresio Avitabile Professor and Chairman Eye Clinic University of Catania; General Secretary Italian Ophthalmological Society (SOI), Rome - Italy https://orcid.org/0000-0002-2966-4981
  • Roberto Bellucci Department of Ophthalmology, Hospital and University of Verona, Verona - Italy
  • Aldo Caporossi Institute of Ophthalmology, Catholic University "Sacro Cuore" Foundation "A. Gemelli", Rome - Italy https://orcid.org/0000-0002-8680-3773
  • Giorgio Marchini Full Professor of Ophthalmology and Chairman, University Eye Clinic, Department of Neurosciences, Biomedicine and Movement, University of Verona; Director of the School of Ophthalmology, University of Verona; AOUI-Borgo Roma Hospital, Verona - Italy https://orcid.org/0000-0002-4657-3168
  • Pasquale Troiano Director of the Eye Unit - Fatebenefratelli "Sacra Famiglia" Hospital, Erba (CO) - Italy
  • Pier Luigi Canonico Department of Pharmaceutical Sciences, University of Piemonte Orientale “Amedeo Avogadro”, Novara - Italy
Keywords: Bronfenac, Cataract surgery, Inflammation management, NSAIDs

Abstract

Inflammation represents the manifestation of the host's vascular and cellular response to tissue damage, hypersensitivity of the immune system or autoimmunity. As soon as the damage is detected, the mechanisms of localization and removal of foreign substances and damaged tissues are triggered. This response is amplified by the activation of inflammatory cells and by the production of chemical mediators derived from arachidonic acid, vasoactive substances and cytokines.
At the ocular level, among the different responses implemented by various inflammation mediators, the action of prostaglandins is mainly expressed in three ways: i) change of intraocular pressure; ii) induction of miosis; iii) increase of protein concentration in the aqueous humor.
Ocular inflammation may continue long after the cessation of the initial cause and may also lead to serious consequences, including permanent vision reduction. For this reason, it is essential to establish a correct and effective therapeutic strategy, which allows to control inflammation, the symptoms and the clinical signs associated with it.
This article therefore deals with therapeutic strategies to control inflammation, with a particular focus on the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in cataract surgery.

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Published
2019-04-15
How to Cite
PiovellaM., AvitabileT., BellucciR., CaporossiA., MarchiniG., TroianoP., & CanonicoP. L. (2019). Inflammation management in ophthalmology: new evidences for cataract surgery and beyond. AboutOpen, 6(1), 5-15. https://doi.org/10.33393/abtpn.2019.166