Role of nibrin in advanced ovarian cancer

 

Authors

  • A. González-Martin Department of Medical Oncology, MD Anderson Cancer Center, Madrid, Spain.
  • M. Aracil PharmaMar R&D, Madrid, Spain.
  • C.M. Galmarini PharmaMar R&D, Madrid, Spain.
  • F. Bellati Department of Gynecological and Obstetrical Sciences and Urological Sciences, Università “Sapienza” of Rome, Rome, Italy.

Keywords:

nibrin, ovarian cancer, trabectedin

Abstract

Nibrin is a protein coded by the NBS1 gene which plays a crucial role in DNA repair and cell cycle checkpoint signalling. Nibrin apparently plays two different roles in ovarian cancer. Firstly, mutation in NBS1 can be implicated in ovarian tumorigenesis. Secondly, in invasive tumours, high expression of nibrin mRNA or protein seems to correlate with a worse prognosis and worse response to treatment. All of these data indicate that nibrin could be involved in the clinical outcome of ovarian cancer patients and that it could be a potential target for this disease.

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Published

2014-04-15

How to Cite

1.
González-Martin A, Aracil M, Galmarini C, Bellati F. Role of nibrin in advanced ovarian cancer:  . CBN [Internet]. 2014 Apr. 15 [cited 2024 Jul. 3];2(1):16-9. Available from: https://journals.aboutscience.eu/index.php/cancerbreakingnews/article/view/259

Issue

Vol. 2 No. 1 (2014): April 2014

Section

Breaking from the Lab

License

Articles published in Cancer Breaking News are distributed under the CC Attribution-NonCommercial-NoDerivatives 4.0 license, which allows third parties to copy and redistribute the material providing appropriate credit and a link to the license but does not allow to use the material for commercial purposes and to use the material if it has been remixed, transformed or built upon.