https://journals.aboutscience.eu/index.php/jcb Journal of Circulating Biomarkers is an international, peer-reviewed, open access scientific journal focusing on all aspects of the rapidly growing field of circulating blood-based biomarkers and diagnostics using circulating protein and lipid markers, circulating tumor cells (CTC), circulating cell-free DNA (cfDNA) and extracellular vesicles, including exosomes, microvesicles, microparticles, ectosomes and apoptotic bodies. AboutScience srl - Piazza Duca d'Aosta 12 - 20124 Milano MI (Italy) en-US Journal of Circulating Biomarkers 1849-4544 https://journals.aboutscience.eu/index.php/jcb/article/view/3396 <p><strong>Background:</strong> This research was performed to evaluate Irisin and Insulin concentrations in Thyroid patients.<br /><strong>Material and methods:</strong> This investigation was performed as a cross-sectional study within the Biochemistry<br />Department at KMC, Mangalore, and the Central Lab at KMCH-AT, Mangalore. Participants were classified into<br />two cohorts: those having regular thyroid function as well as those having thyroid disorder, including both hypothyroid and hyperthyroid patients, with 28 individuals (n = 28) in each category based on thyroid stimulating<br />hormone (TSH) levels obtained during thyroid dysfunction screenings. Socio-demographic variables like height,<br />weight, and body mass index were calculated, along with the assessment of hypertensive or hypotensive conditions. Insulin levels were quantified using an automated analyzer system. Statistical analyses were performed<br />utilizing Easy-R (EZR) version 1.55, developed by Jichi Medical University in Saitama, Japan. The normal distribution<br />of the parameters was evaluated through normality tests, with t-tests and Kruskal-Wallis tests applied as<br />appropriate.<br /><strong>Results:</strong> Irisin levels significantly declined in hypothyroid individuals while showing an insignificant rise in hyperthyroidism. Insulin levels significantly increased in hyperthyroid patients compared to normal and hypothyroid groups. A positive correlation between insulin and irisin was found in hypothyroidism, while a negative correlation was observed in hyperthyroidism.<br /><strong>Conclusion:</strong> Preliminary findings of this study indicate a potential interdependence between Irisin and thyroid<br />levels. Investigating the interaction between the thyroid profile and irisin can pave the way for considering irisin<br />as a biomarker for novel treatment strategies in thyroid disorders and metabolic conditions.</p> Amisha Malhotra Gayathri Rao Aradhana Marathe Sowmya Ananda Jothi Vinod Chandran Copyright (c) 2025 Vinod Chandran, Amisha Malhotra, Gayathri Rao, Aradhana Marathe https://creativecommons.org/licenses/by-nc/4.0 2025-06-09 2025-06-09 14 1 1 4 10.33393/jcb.2025.3396