@article{Adami_Alberti_Andretta_Buzzetti_Bonora_Braggio_Cancian_Concia_Conte_De Boni_Fadda_Ferrarese_Giometto_Leone_Pengo_Pertile_Punzi_Saugo_Scroccaro_Vianello_2015, title={Therapeutic Value and Innovation of a Drug and Criteria for Evaluation: A Multidisciplinary Experience in the Veneto Region: Valore del farmaco, innovazione e criteri di valutazione: Punti fermi, incertezze e livelli di condivisione rilevati attraverso un’esperienza multidisciplinare condotta nella Regione Veneto}, volume={2}, url={https://journals.aboutscience.eu/index.php/grhta/article/view/334}, DOI={10.33393/grhta.2015.334}, abstractNote={Defining therapeutic innovation is a key point to determine the price of newly marketed drugs; however, a pre-requisite for an appropriate management of innovation is that some general rules have been identified to recognize the therapeutic value of any pharmacological agent. These issues are a matter of debate for Regulatory Agencies and for the scientific community as well. Cost-effectiveness principles still represent the main approach to quantify the economic value of a drug based on its clinical effectiveness, and QALYs still represent the main tool to compare outcomes across different therapeutic areas. The main problem in this area is represented by the difficulty in translating general principles into practical decisions. Factors that still hamper the application of the value-based approach include organizational constraints (e.g. drug fixed budgets), the lack of familiarity with cost-effectiveness by most decision-makers, and the history of local decisions.}, number={2}, journal={Global and Regional Health Technology Assessment}, author={Adami, Silvia and Alberti, Alfredo and Andretta, Margherita and Buzzetti, Giuliano and Bonora, Enzo and Braggio, Nicola and Cancian, Maurizio and Concia, Ercole and Conte, Pierfranco and De Boni, Michele and Fadda, Valeria and Ferrarese, Annalisa and Giometto, Bruno and Leone, Roberto and Pengo, Vittorio and Pertile, Paolo and Punzi, Leonardo and Saugo, Mauro and Scroccaro, Giovanna and Vianello, Andrea}, year={2015}, month={Oct.}, pages={107–113} }