@article{Bini_Mennini_Marcellusi_Paoletti_Tomino_2023, title={Budget Impact analysis of a new system of care in Parkinson’s disease patients}, volume={9}, url={https://journals.aboutscience.eu/index.php/grhta/article/view/2413}, DOI={10.33393/grhta.2022.2413}, abstractNote={<p class="abstract"><strong>Objective:</strong> To estimate the economic impact of the introduction of a new care system based on apomorphine and Patient Support Program for motor fluctuations (“on-off” phenomena) in patients with Parkinson’s disease which are not sufficiently controlled by oral anti-Parkinson medication in Italy.</p> <p class="abstract"><strong>Method:</strong> A Budget Impact model was developed to evaluate the new care system in patients with Parkinson’s disease over a 3-years’ time horizon. The comparator treatments included in the analysis were treatments based on apomorphine and levodopa + carbidopa. The analysis was conducted from a National Health Service (NHS) perspective. Costs included in the analysis were acquisition costs and device costs. A deterministic sensitivity analysis was carried out to evaluate the uncertainty of the parameters used. A break-even analysis was conducted to identify the minimum number of subjects that would need to be treated with the new care system to obtain a positive Budget Impact (World With – World Without = 0).</p> <p class="abstract"><strong>Results:</strong> The analysis shows that the introduction of the new care system based on apomorphine could generate a cost saving incurred by the NHS of over € 5.7 million in 3 years. Break-even analysis shows that if it were possible to intercept with the new treatment at least 9 patients treated with apomorphine, there would not be an increase in costs for the NHS.</p> <p class="abstract"><strong>Conclusion:</strong> The new care system would respond to the unmet needs of patients with Parkinson’s disease by generating a reduction in the expenditure incurred by NHS.</p>}, number={1}, journal={Global and Regional Health Technology Assessment}, author={Bini, Chiara and Mennini, Francesco Saverio and Marcellusi, Andrea and Paoletti, Martina and Tomino, Carlo}, year={2023}, month={Jan.}, pages={91–98} }