Drug Target Insights 2021-05-15T08:33:19+00:00 Lucia Steele Open Journal Systems <p><strong>Drug Target Insights (DTI)</strong><em>&nbsp;</em>is an international, peer-reviewed, open access journal, covering current developments in all areas of the field of clinical therapeutics and focusing on molecular drug targets which include disease-specific proteins, receptors, enzymes, and genes. The journal seeks to elucidate the impact of new therapeutic agents on patient acceptability, preference, satisfaction and quality of life. The journal welcomes unsolicited article proposals. All articles are listed on PubMed and are freely available via PubMed Central.</p> <p>&nbsp;</p> Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review 2021-05-15T08:33:19+00:00 Sittichai Khamsai Kittisak Sawanyawisuth Vichai Senthong Panita Limpawattana Jarin Chindaprasirt Pewpan M Intapan Wanchai Maleewong Somsak Tiamkao Verajit Chotmongkol Chetta Ngamjarus <p class="abstract"><strong>Background:</strong> Eosinophilic meningitis (EOM) is an emerging parasitic disease that can be found worldwide, of which acute severe headache is a presenting symptom. Although such headaches may persist for up to 2 months, studies have found corticosteroid to be effective in reducing this symptom. As the most recent systematic review was published in 2015, the aim of this study was to provide a more up-to-date examination of the role of corticosteroids in EOM.</p> <p class="abstract"><strong>Methods:</strong> We included randomized controlled trials of corticosteroid treatment for EOM regardless of comparators. Research articles published in five databases were searched and evaluated. The primary outcome was headache, which was compared among various treatment regimens.</p> <p class="abstract"><strong>Results:</strong> We found a total of 257 articles after duplication removal. Of those, two met the study criteria. According to these studies, oral prednisolone alone or in a combination of albendazole resulted in fewer patients with headache after a 2-week course of treatment compared with placebo (maximum of 9.1% vs. 45.5%). The duration of headache was also shorter in the prednisolone arm vs. placebo (maximum of 5 vs. 13 days). There were no serious side effects reported.</p> <p class="abstract"><strong>Conclusion:</strong> A 2-week course of treatment with oral corticosteroid with or without albendazole reduced headaches in patients with EOM.</p> 2021-03-08T13:42:55+00:00 ##submission.copyrightStatement## Tamarind (Tamarindus indica L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity 2021-05-15T08:33:18+00:00 Ana H. de A. Morais Amanda F. de Medeiros Isaiane Medeiros Vanessa C.O. de Lima Anna B.S. Luz Bruna L.L. Maciel Thais S. Passos <p class="abstract"><strong>Introduction:</strong> Obesity and coronavirus disease (COVID)-19 are overlapping pandemics, and one might worsen the other.</p> <p class="abstract"><strong>Methods:</strong> This narrative review discusses one of the primary mechanisms to initiate acute respiratory distress syndrome, uncontrolled systemic inflammation in COVID-19, and presents a potential candidate for adjuvant treatment. Blocking the S protein binding to angiotensin-converting enzyme 2 (ACE-2) and the 3C-like protease (3CL <sup>pro</sup>) is an effective strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.</p> <p class="abstract"><strong>Results:</strong> Host proteases such as FURIN, trypsin, and transmembrane serine protease 2 (TMPRSS) act in S protein activation. Tamarind trypsin inhibitor (TTI) shows several beneficial effects on the reduction of inflammatory markers (tumor necrosis factor α [TNF-α], leptin) and biochemical parameters (fasting glycemia, triglycerides, and very low-density lipoprotein [VLDL]), in addition to improving pancreatic function and mucosal integrity in an obesity model. TTI may inhibit the action of proteases that collaborate with SARS-CoV-2 infection and the neutrophil activity characteristic of lung injury promoted by the virus.</p> <p class="abstract"><strong>Conclusion:</strong> Thus, TTI may contribute to combating two severe overlapping problems with high cost and social complex implications, obesity and COVID-19.</p> 2021-04-01T11:53:15+00:00 ##submission.copyrightStatement##