Clinical and histological findings following the application of a single session of recombinant enzymes on the face

Thu, 15 Jan 2026 00:00:00 +0000

Introduction: Several factors influence the quality and appearance of the skin, including age, lifestyle, sun exposure, and certain conditions. These elements can have a significant negative impact on some individuals. As a
result, esthetic medicine is increasingly sought after as a solution to counteract these effects, enhancing both
appearance and self-esteem. The objective of the research was to observe the clinical and histological changes
in the skin of five women with photoaging, hyperpigmentation, rhytidosis, or acne scars after a single application
of recombinant enzymes.
Methods: This longitudinal descriptive study was conducted on 5 women aged 47-65, randomly selected.
Photographic records and biopsies were taken before and after the treatment.
Results: Clinical results revealed a significant improvement in skin quality and texture, with reduced skin laxity
and skin repositioning, as well as a decrease in hyperpigmented lesions and acne scars. Histologically, there was a
reduction in hyperkeratosis and collagen basophilia, along with regeneration of elastic and collagen fibers, showing
an increase in their integrity.
Conclusion: A single dose of recombinant enzymes demonstrated improvement in skin quality both clinically and
histologically in 100% of the patients, proving to be a safe, reliable, and easy-to-apply treatment. It achieved high
levels of patient satisfaction, suggesting its potential to replace more invasive procedures.

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Clinical and histological findings following the application of a single session of recombinant enzymes on the face