@article{Menzella_Bagnasco_Bilò_Caminati_Cavaliere_Contoli_De Massimi_Gallo_Matucci_Ottaviano_Rossi_Seccia_Emmi_Canevari_2023, title={Management of patients with chronic rhinosinusitis and nasal polyposis in Italy: expert opinion on the diagnostic-therapeutic approach}, volume={10}, url={https://journals.aboutscience.eu/index.php/aboutopen/article/view/2555}, DOI={10.33393/ao.2023.2555}, abstractNote={<p class="abstract">Chronic rhinosinusitis (CRS) is an inflammatory disease that affects the nasal mucosa and the paranasal sinuses; it can be characterized by nasal polyposis (CRSwNP) in up to 30% of cases. CRSwNP is frequently associated with bronchial asthma and patients affected show a greater severity of clinical disease with a significantly worse quality of life.</p> <p class="abstract2">CRSwNP shows predominantly an underlying activation of type 2 inflammatory pathways with the increase of eosinophils, IgE, interleukin (IL)-4, IL-5 and IL-13. Biological drugs that target inflammatory molecules are currently a therapeutic option recognized by guidelines for the treatment of uncontrolled form of the disease.</p> <p class="abstract">The correct definition of the target patient, the type of biological drug to be used and the timing of intervention are crucial to guarantee a personalized therapy and optimize the cost/effectiveness of the treatment.</p> <p class="abstract">A panel of Italian pneumologists, allergologists, immunologists and ear, nose and throat specialists discussed in a series of virtual expert meetings the main criteria for patient characterization and therapeutic decision, highlighting multidisciplinarity, the constant dialogue between doctor and patient, the organization in networks and the use of registries as strategies to implement the management of CRSwNP patients, to reach the personalization of the treatment and the best use of the biological drug(s).</p>}, number={1}, journal={AboutOpen}, author={Menzella, Francesco and Bagnasco, Diego and Bilò, Maria Beatrice and Caminati, Marco and Cavaliere, Carlo and Contoli, Marco and De Massimi, Alessio and Gallo, Stefania and Matucci, Andrea and Ottaviano, Giancarlo and Rossi, Oliviero and Seccia, Veronica and Emmi, Martino and Canevari, Frank Rikki}, year={2023}, month={Mar.}, pages={43–49} }