The process of mineralisation in the development of human tooth

Authors

  • S Caruso Department of Health, Life and Environmental Sciences, University of L'Aquila
  • S Bernardi Department of Health, Life and Environmental Sciences, University of L'Aquila
  • M Pasini Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa
  • MR Giuca Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa
  • R Docimo Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata"
  • MA Continenza Department of Health, Life and Environmental Sciences, University of L'Aquila
  • R Gatto Department of Health, Life and Environmental Sciences, University of L'Aquila

DOI:

https://doi.org/10.23804/ejpd.2016.4.12.322

Keywords:

Enamel disorders, Germ and tooth development, Tooth mineralisation

Abstract

AIM: Tooth development and mineralisation are processes that derive from different tissues interactions, in particular ectodermal and mesenchymal layers. These interactions are responsible for the formation of unique structures with a particular chemical composition. Despite differences, mineralised tissues are similar and they derive by highly concerted extracellular processes that involve matrix proteins, proteases, and mineral ion fluxes that collectively regulate the nucleation, growth and organisation of forming mineral crystals. This review aims at explaining mineralisation, its stages and when damage occurs and alters the hard tissues structure.