Evaluation of antibiotic mix in Non-instrumentation Endodontic Treatment of necrotic primary molars

Authors

  • N Raslan Tishreen University, Latakia, Syria, Faculty of Dentistry, Department of Pediatric Dentistry
  • O Mansour Tishreen University, Latakia, Syria, Faculty of Pharmacy, Department of Medicinal Chemistry and Drugs Quality Control
  • L Assfoura Tishreen University, Latakia, Syria, Faculty of Dentistry, Department of Pediatric Dentistry

DOI:

https://doi.org/10.23804/ejpd.2017.18.04.04

Keywords:

Antibiotic mix, Necrotic primary molars, Non-instrumentation endodontic treatment, Root resorption

Abstract

AIM: To compare the clinical and radiographic success rates of an antibiotic mix consisting of metronidazole, minocycline and ciprofloxacin (3Mix-MP) and another mix where minocycline was replaced with clindamycin (3Mix-MP-R) in non-instrumentation endodontic treatment (NIET) of necrotic primary molars and to determine the effect of root resorption on the success of the treatment. METHODS: Forty-two necrotic mandibular primary molars from 22 healthy children were randomly assigned to either mixture. Blinded clinical evaluation was conducted after 1, 3, 6 and 12 months by the operator, and blinded radiographic evaluation was conducted at 6 and 12 months follow-ups by other two investigators with inter-examiner reproducibility of 0.95. CONCLUSION: Primary teeth with necrotic pulp can be treated with 3Mix-MP or 3Mix-MP-R irrespective of the degree of root resorption.